Analysis on the disease burden trend and attributable risk factors of common gynecological cancers in China from 1990 to 2021
10.3969/j.issn.1672-8467.2025.06.002
- VernacularTitle:1990-2021年中国常见妇科癌症疾病负担及其归因危险因素分析
- Author:
Xiao-hui ZHOU
1
;
Yi-xin ZOU
;
Zhuo-ying LI
;
Yu-xuan XIAO
;
Dan-dan TANG
;
Yu-xin ZHOU
;
Pei-wen LU
;
Qun XU
;
Yong-bing XIANG
Author Information
1. 上海交通大学医学院公共卫生学院 上海 200025;上海交通大学医学院附属仁济医院肿瘤系统医学全国重点实验室 上海 200127;上海市肿瘤研究所流行病学研究室 上海 200032
- Publication Type:Journal Article
- Keywords:
genital neoplasms;
incidence;
mortality;
disease burden;
time trend;
attributable risk factor;
China
- From:
Fudan University Journal of Medical Sciences
2025;52(6):783-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe and analyze the current status,changing trend and influencing factors of the disease burden of cervical,endometrial and ovarian cancer in China from 1990 to 2021.Methods Data on incidence,mortality,disability-adjusted life year(DALY),and other indicators for cervical,endometrial and ovarian cancer were collected from the 2021 Global Burden of Disease database.Joinpoint regression models were used to analyze time trends,and age-period-cohort(APC)models assessed their impact on incidence and mortality.Spearman correlation analysis was performed to evaluate the relationship between the sociodemographic index(SDI)and the cancer indicators.Finally,the attributable risk factors for the disease burden were analyzed.Results From 1990 to 2021,age-standardized incidence rates of cervical and endometrial cancers in China significantly increased,while ovarian cancer showed no significant change.Age-standardized mortality,DALY,and years of life lost due to premature death(YLL)decreased significantly.The disease burden was heavier in middle-aged and older groups.APC model indicated an increase in cervical cancer incidence and a decrease in mortality over time.Furthermore,the incidence risks of cervical and endometrial cancers were elevated in successive birth cohorts,whereas a lower risk was observed for ovarian cancer.Correlation analysis showed significant associations between cancer incidence and mortality with SDI.Obesity has significantly contributed to the disease burden of common gynecologic cancers in China.Conclusion Mortality rates of cervical,endometrial and ovarian cancer have declined,while the incidence of cervical and endometrial cancers has significantly increased.The trends in incidence and mortality are influenced by age,period and cohort effects.Future efforts should focus on controlling risk factors like obesity to reduce the disease burden.
