Research advances in role of Golgiphagy in sepsis
10.3969/j.issn.1000-4718.2025.06.021
- VernacularTitle:高尔基体自噬在脓毒症中的研究进展
- Author:
Yizhao MA
1
;
Zhenting ZHAO
;
Pengyue ZHAO
;
Xiaohui DU
Author Information
1. 解放军总医院第一医学中心普通外科医学部,北京 100853;南开大学医学院,天津 300071
- Publication Type:Journal Article
- Keywords:
Golgiphagy;
sepsis;
autophagy associated receptors;
organ dysfunction
- From:
Chinese Journal of Pathophysiology
2025;41(6):1229-1234
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis remains a significant challenge for healthcare systems worldwide,despite advancements in diagnostic and therapeutic approaches that have mitigated its impact.The underlying pathophysiological mechanisms of sepsis are not yet fully understood.Autophagy,a cellular stress response,has been shown to play a critical role in the de-velopment of sepsis.Golgiphagy,a specific autophagic process targeting the Golgi apparatus,has been identified as a key factor influencing sepsis pathophysiology.This process operates through autophagy-related receptors and contributes to or-gan damage during sepsis.This review will explore the receptors associated with Golgiphagy,its role in sepsis progres-sion,and its effects on various organs,with the goal of informing treatment strategies for sepsis.
