Cold-inducible RNA-binding protein and sepsis
10.3969/j.issn.1000-4718.2025.06.020
- VernacularTitle:细胞外冷诱导RNA结合蛋白与脓毒症
- Author:
Dongmei YANG
1
;
Ziye MENG
;
Xiaorong WANG
;
Chunyu NIU
;
Zigang ZHAO
Author Information
1. 河北北方学院基础医学院/微循环研究所,河北 张家口 075000
- Publication Type:Journal Article
- Keywords:
cold-inducible RNA-binding protein;
sepsis;
inflammation
- From:
Chinese Journal of Pathophysiology
2025;41(6):1218-1228
- CountryChina
- Language:Chinese
-
Abstract:
Under stress,the cold-inducible RNA-binding protein(CIRP)is translocated from the nucleus to the cytoplasm and subsequently released outside the cell.Extracellular CIRP(eCIRP),acting as a damage-associated mo-lecular pattern,amplifies inflammation through various mechanisms and leads to an uncontrolled inflammatory response,thereby contributing to the occurrence and progression of sepsis and other critical pathological processes.Certain CIRP-tar-geting drugs have demonstrated promising anti-sepsis effects through the reduction of CIRP expression,the decrease of eCIRP release,the neutralization of eCIRP,or the intervention in receptor binding.This review examines the release mechanism of CIRP and the role of eCIRP in the development of sepsis,with the aim of providing new insights for the pre-vention and treatment of sepsis by targeting eCIRP.
