Relationship of monocyte to HDL-C ratio and thromboxane B2 with LAAT of elderly patients with atrial fibrillation
10.3969/j.issn.1009-0126.2025.01.005
- VernacularTitle:单核细胞与高密度脂蛋白胆固醇比值和血栓素B2水平与老年心房颤动左心耳血栓的关系
- Author:
Yuanyuan PAN
1
;
Biao CHENG
;
Xuefei TAO
;
Xiaohan CHEN
;
Jie GAO
;
Minghuan FU
Author Information
1. 610072 成都,四川省医学科学院·四川省人民医院老年内科
- Publication Type:Journal Article
- Keywords:
atrial fibrillation;
thromboembolism;
thromboxane B2;
left atrial appendage
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the association of the changes in monocyte to high density lipo-protein cholesterol ratio(MHR)and thromboxane B2(TXB2)with risk of left atrial appendage thrombus(LAAT)in elderly patients with atrial fibrillation(AF).Methods A retrospective study was conducted on 152 elderly AF patients admitted in our hospital from May 2022 to May 2024.According to the results of transesophageal echocardiography,they were divided into thrombus group(46 cases)and non-thrombus group(106 cases).Blood MHR and TXB2 levels were measured and calculated,and the predictive efficacy of MHR and TXB2 levels for the risk of LAAT was analyzed.Results The thrombus group had older age,larger left atrial diameter(LAD),higher monocyte count,and larger proportion of persistent AF(P＜0.01),while lower LVEF and HDL-C levels when compared with the non-thrombus group(P＜0.05,P＜0.01).The MHR and TXB2 level were significantly higher in the thrombus group than those in non-thrombus group(P＜0.01).Multivariate logistic regression analysis indicated that age(OR=1.244,95％CI:1.022-1.466,P=0.028),persistent AF(OR=29.290,95％CI:4.573-187.610,P=0.000),LAD(OR=1.502,95％CI:1.203-1.876,P=0.000),MHR(OR=1.115,95％CI:1.055-1.178,P=0.000)and TXB2(OR=1.064,95％CI:1.031-1.097,P=0.000)were risk fac-tors for LAAT in elderly AF patients,and LVEF(OR=0.813,95％CI:0.707-0.935,P=0.004)was a protective factor.ROC curve analysis suggested that the AUC value of MHR and TXB2 in evaluating the risk of LAAT in elderly AF patients was 0.767 and 0.829,respectively.Conclusion MHR and TXB2 are abnormally elevated in elderly AF patients with LAAT.They are risk factors affecting the occurrence of LAAT,and have certain predictive value for the risk of LAAT.
