Correlation of two serum markers and electroencephalogram with infarct size and neurological function in patients with ACI
10.3969/j.issn.1009-0126.2025.01.015
- VernacularTitle:两种血清标志物和脑电图与急性脑梗死患者病灶体积及神经功能的相关性研究
- Author:
Jie DING
1
;
Jiankang HUANG
1
;
Hongbo WEN
1
;
Jie WANG
1
;
Pengyu DING
1
;
Peng WANG
1
Author Information
1. 211200 南京市溧水区人民医院(东南大学附属中大医院溧水分院)神经内科
- Publication Type:Journal Article
- Keywords:
brain infarction;
electroencephalography;
insulin-like growth factor Ⅰ;
infarct size;
neu-ron-specific enolase
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(1):68-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of EEG and IGF-1 and NSE with infarct size and NIHSS score in patients with acute cerebral infarction(ACI).Methods A total of 218 patients with freshly diagnosed ACI admitted in our department from August 2021 to December 2022 were enrolled,and according to the lesion volume,they were divided into large-,medium-and small-volume groups(63,103 and 52 cases,respectively).The(δ+θ)/(α+β)ratio(DTABR),brain-spine interface(BSI),and serum IGF-1 and NSE levels were measured in these patients.The cor-relation of the above indicators with the volume of infarct volume by MRI,and NIHSS score at baseline and at 2 and 4 weeks after rt-PA thrombolysis was analyzed.Results The medium-and large-volume groups had significantly lower serum IGF-1 level,and higher NSE level and in-creased DTABR and BSI values than the small-volume group(P＜0.05).When compared with the medium volume group,the serum IGF-1 level was obviously lower,and the NSE level and DTABR and BSI values were higher in the large-volume group(P＜0.05).The DTABR and BSI values and serum NSE level were positively correlated with the infarct size(r=0.563,P=0.000;r=0.318,P=0.038;r=0.673,P=0.000)and baseline NIHSS score(r=0.499,P=0.000;r=0.362,P=0.013;r=0.750,P=0.001).The serum IGF-1 level had a negative correlation with the infarct size(r=-0.572,P=0.000)and baseline NIHSS score(r=-0.438,P=0.001).In addi-tion,positive correlations were observed in DTABR and BSI values,serum NSE level and infarct size with the 2-week and 4-week NIHSS scores,while negative correlations were seen in the ser-um IGF-1 level with the NIHSS scores at the two time points(P＜0.05,P＜0.01).Conclusion EEG parameters,IGF-1 and NSE are significantly correlated with infarct size and NIHSS score af-ter thrombolysis in ACI patients.
