Temporal predictive value of sTREM-1,PCT,and MRP8/14 for ARDS in severe pulmonary tuberculosis patients
10.3969/j.issn.1006-5725.2025.22.012
- VernacularTitle:sTREM-1、PCT与MRP8/14对重症肺结核患者急性呼吸窘迫综合征的时序预测价值
- Author:
Mo DENG
1
;
Mishan JIA
1
;
Yanqing TIAN
1
;
Zhiqing ZHENG
1
;
Hui WANG
1
;
Na HAN
1
Author Information
1. 河北大学附属医院结核科(河北 保定 071000)
- Publication Type:Journal Article
- Keywords:
severe pulmonary tuberculosis;
acute respiratory distress syndrome;
sTREM-1;
procal-citonin;
MRP8/14;
prediction
- From:
The Journal of Practical Medicine
2025;41(22):3552-3557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the temporal predictive value of soluble triggering receptor expressed on myeloid cells-1(sTREM-1),procalcitonin(PCT),and myeloid-related protein 8/14(MRP8/14)for secondary acute respiratory distress syndrome(ARDS)in patients with severe pulmonary tuberculosis.Methods A retro-spective cohort study was conducted among patients with severe pulmonary tuberculosis admitted between January 2021 and December 2024.Patients were randomly assigned in an 8∶2 ratio to a training set(n=148)and a valida-tion set(n=37).Serum sTREM-1,PCT,and MRP8/14 were extracted from the electronic medical record at three time points:on admission(day 0),day 3,and day 7.Multivariable logistic regression was used to identify risk factors,and predictive performance was evaluated using receiver operating characteristic(ROC)curves.Results A total of 185 patients were included.In the training set(n=148),27 developed ARDS and 121 did not;in the validation set(n=37),7 developed ARDS and 30 did not.In the training set,serum sTREM-1,PCT,and MRP8/14 levels showed significant temporal changes(P<0.05).At admission,day 3,and day 7,levels of sTREM-1,PCT,and MRP8/14 were higher in the ARDS group than in the non-ARDS group(all P<0.05).At each time point,sTREM-1,PCT,and MRP8/14 were independently associated with the development of ARDS(P<0.05).In the training set,the combination of sTREM-1,PCT,and MRP8/14 at admission yielded the largest area under the ROC curve[AUC=0.976;95%confidence interval(CI),0.952～1.000],with a sensitivity of 88.9%and a specificity of 98.3%.In the validation set,the same combination achieved an AUC of 0.957(95%CI,0.895～1.000),with a sensitivity of 100.0%and a specificity of 86.7%.Conclusion Dynamic changes in sTREM-1,PCT,and MRP8/14 provide temporal predictive value for ARDS in patients with severe pulmonary tuberculosis,and the combined assessment improves early warning accuracy.
