The value of amide proton transfer imaging combined with diffusion kurtosis imaging in preoperative prediction of lymphovascular space invasion in cervical cancer
10.3969/j.issn.1002-1671.2025.06.022
- VernacularTitle:酰胺质子转移成像联合扩散峰度成像术前预测宫颈癌淋巴脉管间隙侵犯的价值
- Author:
Chen XU
1
;
Xiaoyan ZHANG
;
Junjun WANG
;
Xingchen WU
;
Qianqian QU
;
Kai DENG
Author Information
1. 济宁医学院临床医学院,山东 济宁 272067;山东第一医科大学第一附属医院(山东省千佛山医院)放射科,山东 济南 250000
- Publication Type:Journal Article
- Keywords:
cervical cancer;
lymphovascular space invasion;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(6):999-1002,1025
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of preoperative amide proton transfer(APT)imaging combined with diffusion kurtosis imaging(DKI)in predicting lymphovascular space invasion(LVSI)in cervical cancer.Methods Fifty-one patients with cervical cancer who underwent preoperative MRI examination and had complete postoperative pathology were retrospectively selected.Pelvic MRI scans were performed 1-2 weeks preoperatively,and the corresponding APT values,mean kurtosis(MK)and mean diffusivity(MD)values were obtained respectively,and the occurrence of LVSI was determined based on postoperative pathology results.The predictive effects of APT-and DKI-derived parameters alone or in combination on the LVSI status of cervical cancer were compared.Results Among 51 cases of cervical cancer,36 cases had pathologically confirmed LVSI and 15 cases did not had LVSI.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve for the preoperative APT values,MK and MD values alone and in combination to predict the LVSI status of cervical cancer were 0.820,0.788,0.762,0.894,0.885,and 0.896,respectively.APT values combined with DKI-derived parameters predicted LVSI better than when they were used separately,in which APT values combined with MK and MD values predicted LVSI of cervical cancer with the largest AUC,sensitivity of 91.7％,specificity of 80.0％,and Youden's index of 0.717.Conclusion Preoperative APT imaging and DKI have important value in predicting LVSI of cervical cancer,and the combined application of the two can improve the prediction efficacy,which has certain clinical application value.
