Clinical features and prognostic analysis of adenoid cystic carcinoma of the external auditory canal
10.3969/j.issn.1006-7795.2025.03.022
- VernacularTitle:外耳道腺样囊性癌的临床特征及预后分析
- Author:
Jun WU
1
;
Xi ZHAO
1
;
Tingyao MA
1
;
Guoliang YANG
1
;
Shujing ZHANG
1
;
Yue ZHAO
1
;
Yixuan LIU
1
;
Xiaohong CHEN
1
Author Information
1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京 100730
- Publication Type:Journal Article
- Keywords:
adenoid cystic carcinoma;
perineural invasion;
solid histological pattern;
local recurrence;
comprehensive treatment
- From:
Journal of Capital Medical University
2025;46(3):559-566
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics,treatment strategies,and prognostic factors of adenoid cystic carcinoma(ACC)of the external auditory canal(EAC),and to provide evidence for optimizing surgical extent and adjuvant therapy.Methods A retrospective cohort study was conducted on 58 patients with pathologically confirmed ACC of the EAC treated in Department of Otorhinolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,between January 2001 and December 2021.All patients underwent surgical treatment,with some receiving adjuvant radiotherapy.The primary outcome was local recurrence,while secondary outcomes included overall survival(OS)and local recurrence-free survival(LRFS).Survival analysis was performed by the Kaplan-Meier method,and Cox regression models were used to identify risk factors for recurrence.Results The median follow-up time for the entire cohort was 6.27(3.25,11.30)years.The 1-year,3-year,and 5-year OS rates were 96.55％,91.37％,and 89.66％.43.10％of cases were classified as T4 stage at diagnosis,indicating advanced local progression.Local recurrence occurred in 23 patients(39.66％),and distant metastasis was observed in 28 patients(48.28％),with pulmonary metastasis accounting for 92.86％of cases.Multivariate analysis revealed that the solid histological pattern(HR=2.729,95％CI:1.025-7.226,P=0.044)and perineural invasion(PNI)(HR=9.891,95％CI:3.525-27.752,P＜0.01)were independent risk factors for local recurrence.Conclusion ACC of the EAC is characterized by a high propensity for local recurrence and distant metastasis.The solid histological pattern and perineural invasion are critical prognostic determinants.Multimodal therapy(surgery combined with adjuvant radiotherapy)may improve clinical outcomes,and early diagnosis and intervention are pivotal for enhancing survival rates.
