A study on the distribution patterns of traditional Chinese medicine syndrome types in antipsychotic-induced metabolic syndrome
10.3969/j.issn.1006-7795.2025.03.010
- VernacularTitle:抗精神病药物所致的代谢综合征中医证型分布规律研究
- Author:
Shulian XIAN
1
;
Hongxiao JIA
;
Xue LI
;
Di WANG
;
Mingkang SONG
;
Dongqing YIN
;
Hairong JIANG
Author Information
1. 北京中医药大学第三临床医学院,北京 100029
- Publication Type:Journal Article
- Keywords:
antipsychotic medications;
metabolic syndrome;
traditional Chinese medicine syndrome types;
clustering analysis;
Bayesian network analysis
- From:
Journal of Capital Medical University
2025;46(3):463-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distribution patterns of traditional Chinese medicine(TCM)syndromes in patients with metabolic syndrome caused by antipsychotic drugs.Methods A standardized TCM syndrome survey was performed to collect diagnostic information from 160 patients diagnosed with metabolic syndrome due to antipsychotic drug use.Subsequent frequency analysis,cluster analysis,and Bayesian network analysis were carried out.The syndrome pattern distribution was ultimately determined through relevant literatures and expert opinions.Results Five TCM syndromes were identified through frequency,cluster,and Bayesian network analyses.The most common syndrome was qi deficiency with phlegm-dampness(30％),followed by spleen deficiency with phlegm-Heat(23.75％),qi and yin deficiency Pattern(21.88％),yin deficiency with damp-heat(17.50％),and stomach fire hyperactivity pattern(6.88％).Conclusion The pathogenesis of antipsychotics-induced metabolic syndrome involves a complex interplay of deficiency and excess factors.The primary disease is mainly located at the spleen and stomach,with involvement of the liver,kidney,and heart.Pathogenic factors include qi deficiency,yin deficiency,dampness,heat,pathogenic fire,and phlegm.
