Study on the diagnostic value of diffusion kurtosis imaging parameters in Parkinson's disease with mild cognitive impairment
10.3969/j.issn.1002-1671.2025.06.006
- VernacularTitle:扩散峰度成像参数对帕金森病伴轻度认知障碍患者诊断价值研究
- Author:
Dan LU
1
;
Shulan CUI
1
;
Yuhong LIU
1
;
Pengcheng MA
1
;
Rui HOU
1
;
Jin WANG
1
Author Information
1. 昆明医科大学附属延安医院放射科,云南 昆明 650000
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
mild cognitive impairment;
diffusion kurtosis imaging
- From:
Journal of Practical Radiology
2025;41(6):920-923
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of diffusion kurtosis imaging(DKI)in the diagnosis of Parkinson's disease with mild cognitive impairment(PD-MCI)patients.Methods A total of 18 patients with Parkinson's disease cognitive normal(PDN),22 patients with PD-MCI,and 24 healthy controls(HC)were prospectively included.All participants underwent DKI,and regions of interest(ROI)were selected in the substantia nigra,red nucleus,striatum,and posterior cingulate gyrus for post-processing.The diagnostic efficacy of DKI parameters on PD patients' cognitive status was analyzed by the receiver operating characteristic(ROC)curve.Results Compared with the PDN group,the PD-MCI group had a longer disease duration and a higher H-Y stage.Compared with the HC group,the PD-MCI group showed significantly lower mean kurtosis(MK),radial kurtosis(RK),axial kurtosis(AK),and fractional anisotropy(FA)values in the substantia nigra and posterior cingulate gyrus.In the PDN group,FA and MK values in the substantia nigra were significantly decreased,while FA values in the striatum and posterior cingulate gyrus were significantly increased(P＜0.05).Compared with the PDN group,the PD-MCI group showed significantly decreased DKI parameter values in the substantia nigra and posterior cingulate gyrus,and significantly decreased RK,AK,and FA values in the striatum(P＜0.05).The FA values of striatum,posterior cingulate gyrus and joint predictors were the most effective in the diagnosis of PD-MCI and the area under the curve(AUC)were 0.826,0.853 and 0.960,respectively.Conclusion DKI can detect microstructural changes in PD patients.Microstructural alterations in the striatum and posterior cingulate gyrus have an impact on early cognitive function changes in PD patients.FA demonstrate high sensitivity and specificity in the diagnosis of PD-MCI,and the combined diagnostic efficacy across multiple regions is even higher.
