Research progress on peritoneal metastasis of gastric cancer in the era of immunotherapy
10.3760/cma.j.cn441530-20241008-00032
- VernacularTitle:免疫治疗在胃癌腹膜转移中的应用和挑战
- Author:
Jianqiao YANG
1
;
Kewei JIANG
1
;
Shan WANG
1
Author Information
1. 北京大学人民医院胃肠外科，北京 100032
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Immunotherapy;
Peritoneal metastasis
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(5):557-563
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal metastasis is a common form of metastasis and recurrence in advanced gastric cancer. In recent years, immunotherapy has shown promising applications in the treatment of various malignancies, including gastric cancer. Given the limited efficacy of conventional treatment modalities, such as surgery and chemotherapy, in managing gastric cancer peritoneal metastasis, immunotherapy has garnered increasing attention and recognition among researchers worldwide. However, the application of immunotherapy in gastric cancer peritoneal metastasis still faces significant challenges, including the immunosuppressive tumor microenvironment, drug delivery barriers, and tumor resistance. This review aims to summarize the immunological mechanisms underlying gastric cancer peritoneal metastasis and discuss the latest advances in immunotherapy from both domestic and international studies, with the goal of providing insights for the development of novel immunotherapeutic agents and the optimization of treatment strategies for patients.
