Comparison of chemical constituents in traditional decoction and formula granule decoction of Wendan Decoction
10.3969/j.issn.1001-1528.2025.02.005
- VernacularTitle:温胆汤传统汤剂、配方颗粒汤剂中化学成分比较
- Author:
Tan XUE
1
;
Man-wen XU
;
Xue-hua FAN
;
Feng-yu DONG
;
Yan MIAO
;
Jia-ning SUN
;
Jun-han SHI
;
Lu ZHANG
;
Jing YAO
;
Rui-xin LIU
Author Information
1. 河南中医药大学第一附属医院药学部,河南郑州 450003;河南中医药大学药学院,河南郑州 450046
- Publication Type:Journal Article
- Keywords:
Wendan Decoction;
traditional decoction;
formula granules;
chemical constituents;
HPLC fingerprints;
cluster analysis;
principal component analysis;
multidimensional scaling analysis
- From:
Chinese Traditional Patent Medicine
2025;47(2):384-394
- CountryChina
- Language:Chinese
-
Abstract:
AIM To compare the chemical constituents in traditional decoction and formula granule decoction of classical famous prescription Wendan Decoction.METHODS The HPLC fingerprints were established,after which the contents of adenosine,synephrine,liquiritin,naringin,hesperidin,6-gingerol and adenosine cyclophosphate were determined,cluster analysis,principal component analysis and multidimensional scaling analysis were adopted in the investigation of component differences,and the equivalent of formula granules was adjusted.RESULTS The similarities of HPLC fingerprints for 10 batches of traditional decoctions were higher than those of HPLC fingerprints for 9 batches of formula granule decoctions(P＜0.01).Adenosine,synephrine,liquiritin,hesperidin and cyclic adenosine monophosphate demonstrated higher contents in traditional decoctions than those in formula granule decoctions(P＜0.05),6-gingerol displayed lower content than that in the latter produced by manufacturers A,C(P＜0.05),which was higher than that in the latter produced by manufacturer B(P＜0.01).Various batches of traditional decoctions and formula granule decoctions could be obviously distinguished,adenosine,synephrine and hesperidin exhibited great influences on the classification of principal component analysis,and the quality of formula granule decoctions produced by manufacturer C was closer to that of traditional decoctions.After equivalent correction,the contents of various constituents in formula granule decoctions produced by manufacturers A,C showed no significant differences as compared with those in traditional decoction(P＞0.05).CONCLUSION The formula granules of Wendan Decoction from different manufacturers exist quality differences,so the preparation process and extraction process of this preparation should be optimized to improve quality,and equivalent ratio should be adjusted according to actual requirements to ensure its scientific and rational clinical application.
