Chemical constituents from Asteris Radix et Rhizoma and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2025.02.018
- VernacularTitle:紫菀化学成分及其抗炎活性研究
- Author:
Pei LI
1
;
Fu-xia ZHAO
1
;
Si-qi YANG
1
;
Jin-yan TAN
1
;
Ying-li WANG
1
;
Yan-gang CHENG
1
Author Information
1. 山西中医药大学,山西晋中 030619
- Publication Type:Journal Article
- Keywords:
Asteris Radix et Rhizoma;
chemical constituents;
isolation and identification;
anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2025;47(2):473-479
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Asteris Radix et Rhizoma and their anti-inflammatory activities.METHODS The extract from Asteris Radix et Rhizoma was isolated and purified by column chromatography and high performance liquid chromatography,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their anti-inflammatory activities were evaluated by RAW264.7 model.RESULTS Thirteen compounds were isolated and identified as(Z)-9,10,11-trihydroxy-12-octadecenoic acid(1),tianshic acid(2),6,6-dimethyl-2-methlenebicyclo[3.1.1]hept-3-O-(6-O-apiofuranosyl)-β-D-glucopyranoside(3),ent-16β,17-dihydroxy-kauran-19-oic acid(4),ent-17-hydroxy-19-kauranoic acid(5),7β,17-dihydroxy-16α-ent-kauran-19-oic acid 19-O-β-D-glucopyranoside ester(6),paniculoside Ⅳ(7),thomimarine A(8),cyclo-(S-Pro-R-Leu)(9),4,5-di-O-caffeoylquinic acid 1-methyl ether(10),methyl 3,5-di-O-caffeoyl quinate(11),5-acetyl-3β-hydroxy-2β-(1-hydroxyisopropyl)-2,3-dihydrobenzofurane(12),4-ally-2,6-dimethoxyphenyl glucoside(13).Compounds 1 and 3-12 had inhibition on the release of NO in RAW264.7 cells,and 4-6,8,10-12 were better than the positive control.CONCLUSION Compounds 1,6,8-9 are isolated from Compositae family for the first time,and 2-5,7,10 and 11-13 are first isolated from this plant.Compounds 1,3-12 have anti-inflammatory activities.
