Neuro-immune interactions in the tumor microenvironment: from mechanisms to precision therapy
10.3760/cma.j.cn441530-20250826-00318
- VernacularTitle:肿瘤微环境中的神经-免疫交互：从机制探索到精准治疗
- Author:
Yingjing ZHANG
1
;
Tianping LUO
;
Fenglin LIU
Author Information
1. 复旦大学附属肿瘤医院胃外二科 复旦大学上海医学院肿瘤学系，上海 200032
- Publication Type:Journal Article
- Keywords:
Tumor;
Neuro-immune axis;
Novel combination therapy
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(9):1080-1086
- CountryChina
- Language:Chinese
-
Abstract:
The nervous system, as the core hub of physiological regulation in the human body, plays a key role in the tumor microenvironment through the neuro-immune-tumor axis. Studies have shown that tumor-infiltrating nerve fibers regulate immune cell functions by releasing neurotransmitters, while immune cells can feedback and modulate neuronal activity, forming a dynamic bidirectional interaction network. The emerging field of cancer neuroimmunology focuses on the complex dialogue mechanisms between the nervous and immune systems in the tumor microenvironment. In-depth analysis of the neuro-immune interaction network not only provides new perspectives for understanding tumor immune escape, but also lays the theoretical foundation for developing novel combination therapies targeting the neuro-immune axis, potentially providing breakthrough strategies to overcome resistance to current immunotherapies.
