Long-term Impact of Newly Diagnosed Diabetes on the Incidence and Risk of Severe Microvascular Complications
10.3969/j.issn.1000-3614.2025.06.003
- VernacularTitle:新诊断糖尿病对严重微血管并发症发病率及发病风险的长期影响
- Author:
Qier AN
1
;
Jinping WANG
;
Xinxing FENG
;
Xin QIAN
;
Shuhan ZHOU
;
Siyao HE
;
Hui LI
;
Guangwei LI
;
Yanyan CHEN
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 内分泌中心,北京 100037
- Publication Type:Journal Article
- Keywords:
diabetes;
microvascular complication;
normal glucose tolerance;
cumulative incidence rate
- From:
Chinese Circulation Journal
2025;40(6):571-576
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:There is a lack of long-term follow-up study results on severe microvascular complications in a larger Chinese population with diabetes.This study aims to explore long-term impact of newly diagnosed diabetes(NDD)on the incidence and risk of severe microvascular complications.Methods:A total of 598 NDD and 493 normal glucose tolerance(NGT)subjects were included in this study in 1986.By questionnaire and systematic case review,the occurrence of severe microvascular complications,including severe diabetic retinopathy,severe diabetic nephropathy,and severe diabetic neuropathy,was followed up and collected over a period of 34 years.Results:The cumulative incidence of severe microvascular complications in the NDD population was 65.03%(95%CI:58.90%-70.48%)over 34 years,significantly higher than that in the NGT population(16.8%,95%CI:12.64%-20.11%).After adjusting for related risk factors,the risk of severe microvascular complications in the NDD population was 7.08 times than that of the NGT population(HR=7.08,95%CI:5.09-9.84,P<0.0001).Stratified analysis by sex showed that the cumulative incidence and risk of severe microvascular complications were slightly higher in male NDD population(68.02%,95%CI:57.27%-76.61%;HR=9.45,95%CI:5.78-15.47,P<0.0001)than in female NDD population(63.37%,95%CI:55.69%-70.09%;HR=5.86,95%CI:3.75-9.16,P<0.0001);however,the cumulative incidence increased more rapidly in women during the follow-up period of 10-25 years.Conclusions:The incidence and risk of severe microvascular complications in diabetes were significantly higher than those in the NGT population;and the incidence of severe vascular complications increased rapidly after the duration of diabetes exceeded 10 years,indicating that strict control of blood glucose in the early stage of diabetes is of vital importance.
