Moxibustion combined with low-dose tadalafil for diabetes mellitus-induced erectile dysfunction:A prospective,single-center,three-arm randomized controlled trial
10.13263/j.cnki.nja.2025.01.009
- VernacularTitle:艾灸联合小剂量他达拉非治疗糖尿病性勃起功能障碍临床研究:一项前瞻性、单中心、三臂随机对照试验
- Author:
Tao LIU
1
;
Zhao-xu YANG
1
;
Yan XU
1
;
Qi ZHAO
1
;
Xue LIU
1
;
Xin-fei HUANG
1
;
Zhi-xing SUN
1
;
Yun CHEN
1
;
Jian-huai CHEN
1
Author Information
1. 江苏省中医院/南京中医药大学附属医院男科,江苏南京 210029
- Publication Type:Journal Article
- Keywords:
diabetes mellitus-induced erectile dysfunction;
moxibustion;
tadalafil
- From:
National Journal of Andrology
2025;31(1):55-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of moxibustion(Mox)combined with low-dose tadalafil(TAD)in the treatment of diabetes mellitus-induced erectile dysfunction(DMED)with the syndrome of Qi deficiency and blood stasis.Meth-ods:According to the inclusion and exclusion criteria,we selected 90 patients with DMED for this trial and equally randomized them into a Mox,a TAD,and a Mox combined with TAD(Mox+TAD)group to be treated by mild Mox applied to the acupoints Zusanli,Sanyinjiao and Yinlingquan qd alt,oral medication with low-dose TAD at 5 mg per dose qd,and combination of the above two thera-pies,respectively,all for 4 weeks.We obtained from the patients their IIEF-5 scores,traditional Chinese medicine(TCM)symptoms scores,Erectile Hardness Scale(EHS)scores,corpus cavernosal hemodynamic indexes,and the peak systolic velocity(PSV),end diastolic velocity(EDV)and resistance index(RI)of the corpus cavernosal arteries before and after treatment,and compared them among the three groups.Results:The total effectiveness rate was significantly higher in the Mox+TAD(90.0％)than in the Mox(46.7％)and TAD groups(60.0％)(P＜0.05).Compared with the baseline,the IIEF-5 and EHS scores were increased,while the TCM symptoms scores decreased in all the three groups after treatment,more significantly in the Mox+TAD group than in the other two(P＜0.05).And the PSV and RI were remarkably increased,while the EDV decreased(P＜0.05)in all the three groups(P＜0.05)after treatment,with PSV even higher in the Mox+TAD than in the Mox and TAD groups(P＜0.05).Conclusion:Moxi-bustion combined with tadalafil has a definite efficacy and safety for the treatment of DMED,which can effectively improve the erectile function of the patients by increasing penile blood supply,benefiting qi and activating blood circulation.
