Normothermic intraperitoneal and systemic treatment (NIPS) for gastric cancer with peritoneal metastasis: Japanese experience
10.3760/cma.j.cn441530-20250319-00109
- VernacularTitle:腹腔内常温联合全身治疗（NIPS）在胃癌腹膜转移治疗中的应用——日本经验
- Author:
Kitayama JOJI
1
;
Ishigami HIRONORI
1
;
Yamaguchi HIRONORI
1
Author Information
1. 上海交通大学医学院附属瑞金医院普通外科
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Peritoneal metastasis;
Intraperitoneal chemotherapy;
Normothermic intraperitoneal and systemic treatment (NIPS);
Paclitaxel
- From:
Chinese Journal of Gastrointestinal Surgery
2025;28(5):487-492
- CountryChina
- Language:Chinese
-
Abstract:
Despite advances in targeted therapies, the prognosis for patients with peritoneal metastases (PM) from gastric cancer remains poor, due to the "blood-peritoneal barrier," which limits delivery of systemically administered drugs to peritoneal lesions. Intraperitoneal (IP) administration of paclitaxel (PTX) offers pharmacokinetic advantages by enhancing drug retention and infiltration in peritoneal lesions. Normothermic intraperitoneal and systemic chemotherapy (NIPS), developed in Japan two decades ago, combines repeated IP infusion of PTX via an intraperitoneal access port with systemic chemotherapy, and is currently regarded as one of the most effective treatment modalities for managing PM from gastric cancer. This review provides an overview of the theoretical rationale and clinical outcomes associated with this treatment strategy.
