MiR-708 expression and CXCL13 level in patients with acute myocardial infarction and their associa-tion
10.3969/j.issn.1008-0074.2025.03.04
- VernacularTitle:急性心肌梗死患者miR—708表达和CXCL13水平及其关联研究
- Author:
Yu-lin MU
1
;
Min TAO
Author Information
1. 上海市奉贤区中心医院检验科,上海 201406
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
MicroRNAs;
Chemokine CXCL13
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(3):299-304
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study microRNA-708(miR-708)expression and level of CXC chemokine ligand 13(CX-CL13)in patients with acute myocardial infarction(AMI)and their association.Methods:A total of 60 AMI pa-tients treated in Department of Cardiology,Shanghai Fengxian District Central Hospital between May 2020 and May 2023 were selected as AMI group,another 60 healthy subjects who simultaneously underwent physical examination were regarded as healthy control group.Serum miR-708 expression,levels of CXCL13,creatine kinase isoenzyme MB(CK-MB)and cardiac troponin I(cTnI)were measured.The association of miR-708,CXCL13 with CK-MB and cTnI in AMI patients was analyzed by Pearson correlation analysis.Receiver operating characteristic(ROC)curve was used to analyze diagnostic value of miR-708 and CXCL13 for AMI.Results:Compared with participants in the healthy control group,those in AMI group had significant lower miR-708 expression[(0.54±0.17)vs.(1.05±0.36)],and significant higher levels of CXCL13[(72.44±13.18)pg/ml vs.(48.16±5.72)pg/ml],cTnI[(6.07±2.12)ng/ml vs.(1.77±0.25)ng/ml]and CK-MB[(62.43±12.42)U/L vs.(14.35±3.61)U/L](P＜0.001 all).Pearson correlation analysis revealed a significant inverse correlation of miR-708 expression with CXCL13,cTnI and CK-MB(r=-0.687,P＜0.001;r=-0.559,P＜0.001;r=-0.588,P＜0.001);and a significant positive correlation of CXCL13 level with cTnI and CK-MB(r=0.598,P＜0.001;r=0.580,P＜0.001).ROC curve analysis indicated that the area under the curve(AUC)of miR-708 expression,CXCL13 level and their combination for diagnosing AMI was 0.833(95％0.753～0.912),0.844(95％0.766～0.922)and 0.946(95％0.897～0.995)respectively,and AUC of the combined detection was significantly higher than those of single detections(Z=2.353,2.162,P=0.019,0.031).Conclusion:The expression of miR-708 significantly decreases and CXCL13 level sig-nificantly increases in AMI patients.Their combined detection possess certain diagnostic value for AMI.
