Research progress in animal models and related evaluation indexes of laryngopharyngeal reflux disease
10.3969/j.issn.1671-7856.2025.05.015
- VernacularTitle:咽喉反流性疾病动物模型和相关评价指标的研究进展
- Author:
Xiuhong WEI
1
;
Zhen ZHEN
;
Junbo ZHANG
;
Yanmiao MA
;
Xianyu LI
Author Information
1. 中国中医科学院医学实验中心,北京 100700;山西中医药大学基础医学院,太原 030619
- Publication Type:Journal Article
- Keywords:
laryngopharyngeal reflux disease;
animals;
model;
index evaluation;
progress
- From:
Chinese Journal of Comparative Medicine
2025;35(5):155-163
- CountryChina
- Language:Chinese
-
Abstract:
Laryngopharyngeal reflux disease(LPRD)occurs in the upper respiratory tract and the upper digestive tract.Its pathogenesis is complex and there a lack of effective treatments.Suitable animal models and standard evaluation method are needed to explore the pathogenesis of this disease and to develop new therapeutic drugs.New Zealand rabbits are commonly used to model LPRD,via balloon dilatation.The standard evaluation method for LPRD include symptom observation and evaluation,imaging evaluation,and pH monitoring.This review considers the animal models and evaluation indexes currently used for pharyngeal reflux with reference to the global literature,to provide a reference for future research.
