68 Ga-DOTA-NOC PET/CT for diagnosing pheochromocytoma and paraganglioma
10.13929/j.issn.1003-3289.2025.02.018
- VernacularTitle:68Ga-DOTA-NOC PET/CT诊断嗜铬细胞瘤与副神经节瘤
- Author:
Zhenyu ZHAO
1
;
Lulu ZHANG
1
;
Xiaochen YAO
1
;
Chuan ZHANG
1
;
Fei YU
1
;
Jieping SONG
1
;
Xue XUE
1
;
Guoqiang SHAO
1
;
Feng WANG
1
Author Information
1. 南京医科大学附属南京医院(南京市第一医院)核医学科,江苏南京 210006
- Publication Type:Journal Article
- Keywords:
pheochromocytoma;
paraganglioma;
positron-emission tomography;
tomography,X-ray computed;
receptors,somatostatin
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):268-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of 68Ga-DOTA-NOC PET/CT for diagnosing pheochromocytoma(PCC)and paraganglioma(PGL).Methods Thirty-eight patients with suspected or confirmed PCC/PGL who underwent 68 Ga-DOTA-NOC PET/CT were retrospectively enrolled,among them 20 cases underwent 131I-metaiodobenzylguanidine(MIBG)SPECT/CT during the same period.The value of 68Ga-DOTA-NOC PET/CT for diagnosing PCC/PGL at individual and lesion levels were analyzed and compared to the results of 131I-MIBG SPECT/CT.Results Among 38 cases,there were 20 cases of PCC,14 cases of PGL,1 case of adrenocortical carcinoma and 3 cases of benign adrenal hyperplasia.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of 68 Ga-DOTA-NOC PET/CT for diagnosing PCC/PGL in all 38 cases was 87.88％(29/33),60.00％(3/5),93.55％(29/31),42.86％(3/7)and 84.21％(32/38),respectively.Totally 188 lesions were detected in 34 cases,with detection rate of 89.95％(188/209).For 20 patients who underwent both 2 kinds examinations,the detection rate of bone,lymph node,liver,lung metastases and the overall lesions of 68Ga-DOTA-NOC PET/CT were all higher than those of 131I-MIBG SPECT/CT(all P＜0.05).No significant difference of diagnostic accuracy of PCC/PGL was found between 68 Ga-DOTA-NOC PET/CT and 131I-MIBG SPECT/CT(P＞0.05).Conclusion The value of 68 Ga-DOTA-NOC PET/CT for diagnosing PCC/PGL was comparable to that of 131I-MIBG SPECT/CT,but the former showed higher detection rate of metastases,hence being helpful to staging and risk stratification of PCC/PGL.
