Ultrasound soft markers at 11-14 weeks of gestation for predicting adverse pregnancy outcomes:Meta-analysis
10.13929/j.issn.1003-3289.2025.02.026
- VernacularTitle:孕11～14周超声软指标用于预测不良妊娠结局:Meta分析
- Author:
Xuejia DENG
1
;
Fan YANG
;
Kui ZHANG
Author Information
1. 四川大学华西第二医院超声科出生缺陷与相关妇儿疾病教育部重点实验室,四川成都 610041;成都市成华区妇幼保健院超声科,四川成都 610051
- Publication Type:Journal Article
- Keywords:
fetus;
pregnancy outcome;
ultrasonography,prenatal;
meta-analysis
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):304-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of ultrasound soft markers at 11-14 weeks of gestation for predicting adverse pregnancy outcomes using meta-analysis.Methods Literature about ultrasound soft markers at 11-14 weeks of gestation,including nuchal translucency(NT)thickening,nasal bone dysplasia,reversed or absent venous duct,tricuspid regurgitation and single umbilical artery,for predicting adverse pregnancy outcomes were searched in CNKI,Wanfang Med Online,VIP databases,PubMed,Cochrane Library,Embase and Web of Science databases from January 1,2000 to April 1,2024 by 2 researchers independently.The data were extracted,and the risk of bias was assessed.Stata 17.0 software was used for meta-analysis.Results Totally 37 articles involving 9 673 gravidas were enrolled.Meta-analysis showed that the more positive ultrasound soft markers at 11-14 weeks of gestation,the higher risk of adverse pregnancy outcomes.Among single positive markers,single umbilical artery had the highest incidence of adverse pregnancy outcomes,and NT≥3.0 mm had the highest incidence of chromosome abnormalities in fetuses,while tricuspid regurgitation suggested the lowest possibility of adverse pregnancy outcomes and chromosome abnormalities in fetuses.Conclusion Positive ultrasound soft markers at 11-14 weeks of gestation had certain predictive value for adverse pregnancy outcomes,especially chromosomal abnormalities.
