Impact of ginger-processed Jiangxiangru polysaccharides on establishment of a breast cancer tumor-bearing nude mice model and its pathological characteristics
10.3969/j.issn.1005-4847.2025.05.004
- VernacularTitle:乳腺癌荷瘤裸鼠模型证候属性和姜制江香薷多糖的影响
- Author:
Shuai HUANG
1
;
Qiuting MA
;
Tao HONG
;
Xiangming ZHONG
;
Wenkai ZHANG
;
Yun HUANG
;
Zhiyong LIU
Author Information
1. 江西中医药大学实验动物科技中心,南昌 330004
- Publication Type:Journal Article
- Keywords:
ginger-processed Jiangxiangru;
breast cancer;
disease combination model;
TCM symptoms
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(5):656-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the characteristic symptoms in breast cancer-bearing mice and the beneficial effect of ginger-processed Jiangxiangru polysaccharides on traditional Chinese medical symptoms.Methods Thirty-eight mice were used for modeling and divided into normal,model,positive,and low-,medium-,and high-dose ginger-processed Jiangxiangru polysaccharide groups.Mice in the normal group were not inoculated with tumors and mice in the normal and model groups received physiological saline intragastrically.Mice in the positive group received celecoxib solution intragastrically,and mice in the low-,medium-,and high-dose groups received the same dose but different concentrations of ginger-processed Jiangxiangru polysaccharide solution intragastrically.Changes in body weight and tumor size were recorded after 4 weeks of continuous administration.Symptoms were observed at the end of the experiment.RGB values in photographs of the tongues,tails,and claws from mice in each group were analyzed and recorded.The degrees of blood deficiency,yin deficiency,and tumor phlegm stasis were calculated based on the method of quantitative dialectical diagnosis.The tumors were isolated and weighed,and the tumor volume and inhibition rate were calculated to determine the beneficial effect of ginger-processed Jiangxiangru polysaccharides on traditional Chinese medical symptoms.Results Mice in the breast cancer model group showed signs of blood deficiency,yin deficiency,and phlegm stasis.Tumor size was significantly reduced in mice in the ginger-processed Jiangxiangru polysaccharide groups.Ginger-processed Jiangxiangru polysaccharides inhibited tumor growth and improved blood deficiency,yin deficiency,and tumor phlegm stasis in breast cancer-bearing mice,with the best result in the high-dose group.Conclusions Ginger-processed Jiangxiangru polysaccharides can improve the symptoms of blood deficiency,yin deficiency,and tumor phlegm stasis in breast cancer-bearing mice,especially at high doses.
