Research progress on roles of tumor-associated macrophages in tumorigenesis,development,and drug resistance in gastric carcinoma
10.3969/j.issn.1671-7856.2025.05.016
- VernacularTitle:TAM在胃癌发生发展及耐药中的研究进展
- Author:
Qiuling CAI
1
;
Jing YANG
1
;
Huiling SHEN
1
;
Wenlin XU
1
Author Information
1. 江苏大学附属第四人民医院中心实验室,江苏镇江 212000;江苏大学医学院,江苏镇江 212000
- Publication Type:Journal Article
- Keywords:
tumor-associated macrophage;
M2 type macrophage;
gastric carcinoma;
prognosis;
drug resistance
- From:
Chinese Journal of Comparative Medicine
2025;35(5):164-176
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages(TAM)are a current focus in the study of the tumor microenvironment.To achieve their functionally distinct roles,macrophages undergo phenotypic polarization resulting in two major subgroups:M1 macrophages with pro-inflammatory and anti-tumor effects,and M2 macrophages with anti-inflammatory and pro-tumor effects.Of these,M2 polarization,as the main manifestation of TAMs,has been associated with a poor prognosis in various cancers and has been shown to support malignancies.Gastric carcinoma has a low early-diagnosis rate,late disease stage,and poor prognosis,with biological behavioral characteristics of easy recurrence and metastasis.Drug resistance and toxic side effects currently limit the application and effectiveness of treatments,and there is thus an urgent need to explore new therapeutic drugs and targets.This review summarizes recent progress in studies of TAM in relation to the occurrence,development,and drug resistance of gastric carcinoma,providing new ideas for clinical treatment and prognosis prediction in patients with gastric carcinoma.
