Application effect of esketamine pretreatment in laparoscopic high ligation of hernia sac in children
- VernacularTitle:艾司氯胺酮预处理在儿童腹腔镜下疝囊高位结扎术中的应用效果
- Author:
Qiao-lin ZHOU
1
;
Xiao-yan XU
1
;
Feng-yu TAO
1
;
Jiao-hui SHI
1
;
Qi-fei ZHU
1
;
Tao WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: esketamine; laparoscopic surgery; high ligation of hernia sac; anxiety; lung injury; postoperative recovery
- From: Journal of Regional Anatomy and Operative Surgery 2025;34(11):977-980
- CountryChina
- Language:Chinese
- Abstract: Objective To determine the application effect of esketamine pretreatment in laparoscopic high ligation of hernia sac in children.Methods A total of 70 children who received laparoscopic high ligation of hernia sac under general anesthesia were selected and divided into the control group and the observation group according to the random number table method,with 35 cases in each group.The control group received conventional general anesthesia,while the observation group was intravenously injected with 0.5 mg/kg of esketamine 15 minutes before the induction of general anesthesia.The preoperative anxiety score,respiratory mechanics indexes,lung injury status,anesthesia recovery,and adverse reactions during the awakening period were compared between the two groups.Results The anxiety scores of the observation group 10 minutes before anesthesia and immediately before anesthesia were significantly lower than those of the control group(P<0.05).The peak airway pressure and mean airway pressure of the observation group 30 minutes after establishing pneumoperitoneum and at the end of the operation were significantly lower than those of the control group(P<0.05).The levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)at the end of the operation in the observation group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the time of spontaneous breathing recovery,time to regain consciousness,tracheal extubation time,or post-anesthesia care unit(PACU)stay time between the two groups(P>0.05).The incidence of adverse reactions during the anesthetic awakening period in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Esketamine pretreatment can significantly alleviate preoperative separation anxiety for children undergoing laparoscopic high ligation of hernia sac,reduce lung injury,and decrease airway pressure,which is beneficial to lung protection and postoperative anesthetic recovery,and has few adverse reactions.
