Correlation between cortical thickness and pathological deposition ofβ-amyloid in patients with Alzheimer disease
10.13929/j.issn.1003-3289.2025.02.006
- VernacularTitle:阿尔茨海默病患者大脑皮层厚度与β淀粉样蛋白病理性沉积的相关性
- Author:
Lyuming ZHU
1
;
Junwen HOU
;
Zhimin ZHONG
;
Jingjie GE
;
Yue WU
;
Shengwen CHEN
;
Jianhua LUO
;
Yunhao YANG
;
Jing WANG
;
Huamei LIN
;
Chuantao ZUO
;
Yihui GUAN
Author Information
1. 兴国县人民医院赣南医科大学附属兴国医院医学影像科,江西赣州 342400
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
cognition disorders;
cerebral cortex;
amyloid;
magnetic resonance imaging;
positron-emission tomography
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):207-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation between cortical thickness and pathological deposition of β-amyloid(Aβ)in patients with Alzheimer disease(AD)induced mild cognitive impairment(MCI)or dementia.Methods Totally 22 AD patients were prospectively enrolled and divided into dementia group(n=12)and MCI group(n=10)based on the degree of cognitive impairment,while 17 healthy individuals without cognitive impairment were recruited as control group.MR examination and 18F-florbutaben(18F-FBB)PET imaging were performed,the cortical thickness and Aβ deposition value(Centiloid[CL]value)were calculated and compared among 3 groups and between each 2 groups,then the correlation between the above two indexes was analyzed.Results The cortical thickness in dementia group,MCI group and control group was(2.18±0.14),(2.35±0.08)and(2.36±0.09)mm,respectively,with significant difference among 3 groups(P＜0.05).The cortical thickness in dementia group was significantly thinner than that in MCI group and control group(both P＜0.05).CL value in dementia group,MCI group and control group was 77.97(63.07,95.55),65.51(54.54,90.50)and-1.17(-9.66,4.88),respectively,with significant difference among 3 groups(P＜0.05).CL value in dementia group and MCI group were significantly higher than in control group(both P＜0.05).The cortical thickness was moderately negatively correlated with CL value in MCI group(r=-0.580,P=0.048)but not in the other 2 groups(both P＞0.05).Conclusion The cortical thickness was moderately negatively correlated with abnormal deposition of Aβ in patients with AD induced MCI,but was not during dementia.
