Analyzing correlations of volume percentage and metabolism of brain region in patients with Alzheimer disease based on FDG PET/MR
10.13929/j.issn.1003-3289.2025.02.005
- VernacularTitle:基于FDG PET/MR分析阿尔茨海默病患者不同脑区占全脑百分比与脑代谢的相关性
- Author:
Yinyan ZHU
1
;
Yan ZHANG
;
Gan HUANG
;
Mei XIN
;
Peizhe YUAN
;
Yue WANG
;
Liangrong WAN
;
Cheng WANG
;
Gang HUANG
;
Jianjun LIU
;
Chenpeng ZHANG
Author Information
1. 上海交通大学医学院附属仁济医院核医学科,上海 200127
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
positron-emission tomography;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):203-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate correlations of the ratio of specific brain region volume to total brain volume(ratio％),standard uptake value(SUV)of specific brain region based on 18F-FDG PET/MR examination in Alzheimer disease(AD)patients,as well as the relationship between changes of these two.Methods Fifty AD patients were retrospectively collected.Based on FDG PET/MR,the ratio％and the mean SUV(SUVmean)of 40 specific brain regions were obtained,and the correlation between ratio％and SUVmean for each region were evaluated.According to a database of normal brains,Z-scores for ratio％and SUVmean were calculated to represent structural and functional changes in AD patients,and the correlation between these 2 Z-scores was assessed.Results Correlations were found between ratio％and SUVmean,also between Z-scores of these two parameters in 29 brain regions(r=0.288 to 0.778,all P＜0.05).Among them 7 brain regions,i.e.bilateral middle temporal gyrus,right fusiform gyrus,right hippocampus,right precuneus,left lingual gyrus and right parahippocampal gyrus exhibited correlation coefficients greater than 0.6.Conclusion There were some relationships between brain structural and metabolic functions and their changes in AD patients showed on FDG PET/MR.
