Correlations of functional connectivity and glucose metabolism of insular subregions with cognitive function in behavior variant of frontotemporal dementia patients
10.13929/j.issn.1003-3289.2025.02.004
- VernacularTitle:行为变异型额颞叶痴呆患者岛叶亚区功能连接及葡萄糖代谢与认知功能的相关性
- Author:
Sheng BI
1
;
Zhigeng CHEN
;
Yujie HE
;
Hanxiao XUE
;
Zhigang QI
;
Jie MA
;
Hongwei YANG
;
Liyong WU
;
Shaozhen YAN
;
Jie LU
Author Information
1. 首都医科大学宣武医院放射与核医学科,北京 100053;磁共振成像脑信息学北京市重点实验室,北京 100053;教育部神经变性病重点实验室,北京 100053
- Publication Type:Journal Article
- Keywords:
dementia;
cerebral cortex;
magnetic resonance imaging;
fluorodeoxyglucose F18;
positron-emission tomography;
functional connectivity
- From:
Chinese Journal of Medical Imaging Technology
2025;41(2):196-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the functional connectivity and glucose metabolism of insular subregions in behavior variant of frontotemporal dementia(bvFTD)patients,also their correlations with cognitive function.Methods Thirty-eight bvFTD patients(bvFTD group)and 44 healthy individuals(control group)were retrospectively enrolled.The average time series signals of insular subregions were extracted as seed points based on functional MRI(fMRI)and 18F-FDG PET,then whole brain functional connectivity map was obtained.Meanwhile,the pons was selected as the reference brain region,and the standard uptake value ratio(SUVR)of insular subregions were calculated.The above parameters were compared between groups,and the correlations of SUVR of insular subregions with clinical cognitive function scale scores in bvFTD group were analyzed.Results Compared with control group,the functional connections between all insular subregions and bilateral frontal lobe,temporal lobe,anterior cingulate gyrus,anterior cingulate gyrus and middle cingulate gyrus,as well as between some subregions and bilateral parietal and occipital lobes were weakened in bvFTD group(GRF correction,voxel level all P＜0.001,cluster level all P＜0.05).SUVR of all insular subregions significantly decreased(GRF correction,voxel level all P＜0.001,cluster level all P＜0.05),which in right ventral agranular insula(vIa),dorsal agranular insula(dIa),dorsal dysgranular insula(dId)and left dorsal agranular insula(dIa)were negatively correlated with frontal behavioral inventory(FBI)score in bvFTD group(r=-0.452--0.330,all P＜0.05).Conclusion In bvFTD patients,the functional connectivity and glucose metabolism of insular subregions changed,and SUVR of right vIa,dIa,dId and left dIa were negatively correlated with FBI score.
