Research progress of eATP-mediated MC degranulation in allergic diseases
10.3969/j.issn.1000-484X.2025.11.036
- VernacularTitle:胞外ATP介导肥大细胞脱颗粒在过敏性疾病中的研究进展
- Author:
Lan HAN
1
;
Yunfang AN
1
;
Zhishou ZHANG
1
;
Fengli CHENG
1
;
Yibo CHEN
1
;
Changqing ZHAO
1
Author Information
1. 山西医科大学第二医院,山西省气道炎性疾病神经免疫研究(省级重点培育)实验室,气道过敏性疾病快速诊断及治疗山西省重点实验室(筹),太原 030000
- Publication Type:Journal Article
- Keywords:
Extracellular ATP;
Purinergic receptor;
Mast cell;
Allergic inflammation
- From:
Chinese Journal of Immunology
2025;41(11):2769-2773
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine triphosphate(ATP),as a rich energy currency in cells,is released into the extracellular space through a variety of regulatory mechanisms.The role of extracellular ATP(eATP)and related purine and pyrimidine nucleotides as extracellu-lar signal molecules regulating immune cell function has been reported as evidence of purine signal transduction and has become the focus of attention as a therapeutic target for various diseases.Mast cells(MC)are distributed in tissues that come into contact with the external environment and are the first immune cells to respond to non-microbial environmental antigens.Although eATP is considered to be an activator of MC,the details remain to be further elucidated.This article describes the role of purine receptor signaling in MC degranulation.It expands the further understanding of the mechanism of allergic diseases,and further provides ideas for finding new targets for the treatment of allergic diseases and formulating new treatment strategies.
