Effect of PHC combined with RIPC on postoperative cognitive function in patients with lung cancer
10.3969/j.issn.1673-9701.2025.04.002
- VernacularTitle:PHC联合RIPC对肺癌患者术后认知功能影响研究
- Author:
Hua CHAI
1
;
Yulong DU
1
;
Wenyong PENG
1
Author Information
1. 金华市中心医院麻醉科,浙江金华 321000
- Publication Type:Journal Article
- Keywords:
Permissive hypercapnia;
lung cancer;
Remote ischemic preconditioning;
Regional brain oxygen saturation;
Postoperative cognitive dysfunction
- From:
China Modern Doctor
2025;63(4):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of permissive hypercapnia(PHC)combined with remote ischemic preconditioning(RIPC)on regional brain oxygen saturation(rSO2)and postoperative cognitive function in patients undergoing thoracoscopic radical resection for lung cancer.Methods A total of 80 patients who underwent thoracoscopic lung cancer resection in Jinhua Municipal Central Hospital from January to December 2022 were selected and divided into control group,RIPC group,PHC group and PHC+RIPC group according to random number table method,with 20 cases in each group.rSO2 levels were observed before anesthesia induction(T0),before unilateral ventilation(T1),10min after unilateral ventilation(T2),30min after unilateral ventilation(T3),at the end of after unilateral ventilation(T4)and after surgery(T5)in four groups.The level of serum interleukin(IL)-6,IL-10,tumor necrosis factor-α(TNF-α)and cognitive function at T0,T4,the first day after surgery(T6)and the third day postoperative(T7)were recorded.Results After surgery,the levels of IL-6,TNF-α,and IL-10 in four groups first increased and then decreased(P＜0.05).At T4 and T6,there were statistically significant differences in IL-6 levels among four groups(P＜0.05),and the IL-6 level of control group was significantly higher than that of other three groups(P＜0.05).At T4,T6 and T7,there were statistically significant differences in IL-10 and TNF-α levels among four groups(P＜0.05),and the IL-10 level in control group was significantly lower than that in other three groups,and the TNF-α level was significantly higher than that in other three groups.At T2,T3,T4 and T5,there were statistically significant differences in rSO2 between four groups(P＜0.05),and PHC+RIPC group＞RIPC group＞PHC group＞control group.At T6,the score of mini-mental state examination scale of control group was significantly lower than that of other three groups(P＜0.05).Conclusion PHC combined with RIPC can improve rSO2 and postoperative cognitive function in patients with thoracoscopic lung cancer resection,reduce the level of inflammatory factors,and reduce the occurrence of postoperative cognitive dysfunction.
