Mechanism of Lactylation in Ischemic Heart Diseases
10.13865/j.cnki.cjbmb.2025.03.1468
- VernacularTitle:乳酰化修饰在缺血性心脏病中的作用机制
- Author:
Peng-Fei WANG
1
;
Feng-Li HU
1
;
Guo-Qiang GU
1
Author Information
1. 河北医科大学第二医院心内科,石家庄 050000
- Publication Type:Journal Article
- Keywords:
lactylation(Kla);
ischemic heart disease(IHD);
epigenetics;
post-translational modification
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(5):645-652
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic heart disease(IHD)is one of the major threats to global health,characterized by complex and incompletely elucidated pathogenesis.Recently,with the continuous advancement of epige-netic research,lactylation(Kla),a newly discovered type of protein post-translational modification,has gradually attracted attention.Kla significantly influences the pathophysiological processes and cellular molecular functions of IHD by directly affecting gene transcription,signal transduction,and metabolic pathways.Kla extensively occurs in both histones and non-histone proteins and participates in regulating protein functions involved in various pathological processes.By modulating enzymatic activities and signal transduction pathways,Kla affects multiple processes in cardiomyocytes,including energy metabolism,inflammatory response,angiogenesis,lipid metabolic disorders,apoptosis,fibrosis,and myocardial re-pair.Although current studies on specific mechanisms and therapeutic targets of Kla in IHD remain limit-ed,its potential therapeutic value cannot be overlooked.This review summarizes the mechanisms and re-search progress of Kla in critical pathological stages of IHD,such as myocardial infarction,myocardial is-chemia-reperfusion injury,heart failure,and cardiac hypertrophy.Furthermore,we discuss the potential therapeutic targets and application prospects of Kla,aiming to provide insights and directions for identif-ying effective intervention strategies and opening new avenues for the prevention and treatment of IHD.
