Efficacy of Biling Weitong Granules Combined with Morodan in the Treatment of Elderly Patients with Hp-Positive Chronic Atrophic Gastritis and its Influence on Inflammatory Factors and Gastrointestinal Function
10.13241/j.cnki.pmb.2025.19.007
- VernacularTitle:荜铃胃痛颗粒联合摩罗丹治疗老年Hp阳性慢性萎缩性胃炎的疗效及对炎性因子和胃肠功能的影响
- Author:
Yu HUANG
1
;
Xi-li CHEN
1
;
Ai-jing HONG
1
;
Huan-huan HUANG
1
Author Information
1. 江西省九江市经济技术开发区人民医院消化内科 江西九江 332000
- Publication Type:Journal Article
- Keywords:
Biling Weitong Granules;
Morodan;
Elderly;
Helicobacter pylori;
Chronic atrophic gastritis;
Efficacy;
Inflammatory factors;
Gastrointestinal function
- From:
Progress in Modern Biomedicine
2025;25(19):3084-3090
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of Biling Weitong Granules combined with Morodan in the treatment of elderly patients with Helicobacter pylori(Hp)-positive chronic atrophic gastritis(CAG)and its influence on inflammatory factors and gastrointestinal function.Methods:A total of 102 elderly patients with Hp-positive CAG who were admitted to our hospital from April 2023 to September 2024 were prospectively included,the syndrome differentiation type in traditional Chinese medicine is qi stagnation and blood stasis type.According to the envelope lottery method,the patients were divided into control group(n=51 cases,treated with Morodan)and study group(n=51 cases,treated with Biling Weitong Granules combined with Morodan).The clinical efficacy,Hp eradication rate,traditional Chinese medicine syndrome scores,inflammatory factors[C-reactive protein(CRP),interleukin-1 β(IL-1 β),tumor necrosis factor-α(TNF-α)]and gastrointestinal function indicators[gastrin(GAS),pepsinogen Ⅰ(PG Ⅰ)/pepsinogen Ⅱ(PG Ⅱ),gastrin 17(G-17)]and the occurrence of adverse reactions were compared between the two groups.Results:Compared with the control group 2 weeks after treatment,the total effective rate,Hp eradication rate,GAS and PG Ⅰ/PG Ⅱ levels in the study group were higher,while the main symptom score,secondary symptom score,total score,CRP,TNF-α,IL-1[3 and G-17 levels were lower(P＜0.05).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Biling Weitong Granules combined with Morodan in the treatment of elderly patients with Hp-positive CAG,can improve the clinical therapeutic effect and Hp eradication rate,inhibit the inflammatory response,and improve gastrointestinal function.
