Clinical features of cognitive function,neuroendocrine and inflammatory cytokines in patients with chronic tension type headache and insomnia
10.3969/j.issn.1004-1648.2025.03.007
- VernacularTitle:慢性紧张型头痛共病失眠患者认知、神经内分泌功能及炎症细胞因子的临床特征
- Author:
Mingxin HUANG
1
;
Xiaoqing DENG
1
;
Kai CHEN
1
Author Information
1. 530028 南宁,广西医大开元埌东医院神经内科
- Publication Type:Journal Article
- Keywords:
chronic tension type headache;
insomnia;
cognitive function;
neuroendocrine;
inflamma-tory cytokines
- From:
Journal of Clinical Neurology
2025;38(3):194-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical features of cognitive function,neuroendocrine and inflammatory cytokines in patients with chronic tension type headache(CTTH)and insomnia.Methods From April 2020 to December 2020,58 patients with CTTH comorbid insomnia in our hospital were selected as the research group,and 58 healthy individuals who underwent physical examinations during the same period were selected as the control group.Pain severity was assessed by the Visual Analog Scale(VAS),sleep quality was evaluated by the Pittsburgh Sleep Quality Index(PSQI),and overall cognitive function was evaluated by the Montreal Cognitive Assessment Scale(MoCA).The serum cortisol(Cor),adrenocorticotropic hormone(ACTH),C-reactive protein(CRP),TNF-α,and IL-6 were measured.Results The VAS and PSQI scores of the research group were significantly higher than those of the control group,while the MoCA score was significantly lower than that of the control group(all P＜0.05).Compared to the control group,the serum levels of Cor,ACTH,CRP,TNF-α,and IL-6 in the research group were significantly increased(all P＜0.05).The VAS,PSQI scores,serum Cor,ACTH,CRP,TNF-α,and IL-6 levels of patients with moderate headache in the research group were significantly higher than those of patients with mild headache,while the MoCA score was significantly lower than that of patients with mild headache(all P＜0.05).The VAS and PSQI scores of the research group showed a significant negative correlation with the MoCA score,and significant positive correlation with the levels of serum Cor,ACTH,CRP,TNF-α,and IL-6,the VAS score showed significant positive correlation with PSQI score(all P＜0.05).Conclusion CTTH comorbidity insomnia has a certain degree of cognitive decline,which may be related to neuroendocrine disorders and overexpression of inflammatory cytokines.
