Noninvasive assessment of liver function reserve in NAFLD patients by 13C-MBT based on infrared isotope spectrometry
10.3969/j.issn.1672-8270.2025.01.015
- VernacularTitle:基于红外线同位素能谱分析仪的13C-MBT对非酒精性脂肪肝病患者肝功能储备的无创评估
- Author:
Qian WEN
1
;
Yajing XIAN
1
;
Li YANG
1
;
Hua KE
1
;
Lulu DU
1
;
Dongling LIN
1
Author Information
1. 新疆医科大学第一附属医院感染病肝病一科 乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
Nonalcoholic fatty liver disease (NAFLD);
13C-methacetin breath test (13C-MBT);
Liver function reserve;
Liver fibrosis;
Infrared isotope spectrometer;
Elastography imaging
- From:
China Medical Equipment
2025;22(1):76-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the value of noninvasive assessment of the 13C-methacetin breath test (13C-MBT) based on infrared isotope spectrometry for liver function reserve in patients with nonalcoholic fatty liver disease (NAFLD). Methods:A total of 120 NAFLD patients met the diagnostic criteria,who admitted to Department of Liver Diseases of the First Affiliated Hospital of Xinjiang Medical University from January 2023 to January 2024,were prospectively selected. Patients were divided into three groups based on liver stiffness measurement (LSM) of FibroTouch:mild fibrosis group (LSM<7.0 kPa,n=40),moderate fibrosis group (7.0≤LSM<9.5 kPa) and severe fibrosis group (LSM≥9.5 kPa,n=40). Meanwhile,40 healthy subjects were selected as a healthy control group. All subjects underwent 13C-MBT and conventional liver function tests. The differences of 13C-MBT parameters and liver function indicators among various groups were compared,and the correlations between 13C-MBT parameters and the degree of liver fibrosis,and between liver function indexes and the degree of liver fibrosis were analyzed. Receiver operating characteristic (ROC) curve was used to evaluate the judgment ability of 13C-MBT parameters to the degree of liver fibrosis. Results:The 13C-MBT parameters in NAFLD patients were lower than those in healthy control group,and the differences were statistically significant (F=27.413,28.635,29.851,P<0.05). With the aggravation of liver fibrosis,13C-MBT parameters in NAFLD patients gradually decreased. The 13C-MBT parameters of severe fibrosis group were significantly lower than those in the mild and moderate fibrosis groups,with statistically significant differences (t=12.331,13.020,14.232,22.033,21.032,29.332,P<0.05),respectively. The 13C-MBT parameters were positively correlated with liver function indicators,and were negatively correlated with LSM,and the absolute values of the correlation coefficients were>0.5,all of them showed statistically significant differences (r=0.375,-0.875,P<0.05). The 13C-MBT parameters had higher sensitivity and specificity in judging the degree of liver fibrosis. Taking MVmax40 as an example,when the limit value was 9.5 kPa,the sensitivity was 86.3％,and the specificity was 83.8％,and the accuracy was 85.0％,and the area under curve (AUC) was 0.913. Conclusion:13C-MBT based on infrared isotope spectrometry is a non-invasive,safe,rapid and accurate detection method,which can reflect the liver function reserve and liver fibrosis degree of NAFLD patients,and has important clinical value for the diagnosis and treatment of NAFLD.
