Clinical features,therapeutic effects and relapse factors of adults with anti-myelin oligodendrocyte glycoprotein-IgG antibody associated diseases
10.3969/j.issn.1004-1648.2025.03.006
- VernacularTitle:成人髓鞘少突胶质细胞糖蛋白抗体相关疾病临床特点、疗效及复发因素分析
- Author:
Shang LEI
1
;
Wenbin WAN
;
Changhong YUAN
Author Information
1. 233030 蚌埠医科大学研究生院
- Publication Type:Journal Article
- Keywords:
anti-myelin oligodendrocyte glycoprotein-IgG antibody associated diseases;
double filtration plasmapheresis;
therapeutic effects;
relapse
- From:
Journal of Clinical Neurology
2025;38(3):188-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features,therapeutic effects and relapse factors of anti-myelin oligodendrocyte glycoprotein-IgG antibody associated diseases(MOGAD)in adult patients.Methods The clinical data of 15 adult patients with MOGAD were retrospectively analyzed.The patients were divided into conventional treatment group and plasma exchange group according to the treatment.The efficacy was analyzed by comparing the scores of mRS and expanded disability status scale(EDSS)before and after treatment.And the patients were divided into single course group and relapse course group according to the course of disease,and the relapse-related factors were analyzed.Results There were 10 patients in the conventional treatment group and 5 patients in the plasma exchange treatment group,and the mRS and EDSS of the two groups were significantly lower after treatment than those before treatment(all P＜0.05).There were no significant differences in mRS and EDSS scores between the plasma exchange group and the conventional treatment group after treatment(all P＞0.05).There were 11 patients in the unidirectional course group and 4 patients in the relapsing course group.There were no significant differences between the two groups in gender,age,severity of disease,clinical phenotype,antibody titer,and treatment plan in the acute stage(all P＞0.05).The detection rate of OCB in CSF of patients with relapse course was significantly higher than that of patients with single course.The proportion of patients with maintenance oral hormone duration＜6 months in recurrent disease course group was significantly higher than that in single disease course group(all P＜0.05).Conclusions MOGAD patients respond effectively to glucocorticoid pulse therapy and double filtration plasmapheresis during the acute phase,with a favorable prognosis.MOGAD have a risk of recurrence,those who present with encephalitis at the onset,have positive OCB in CSF,and have a shorter duration of oral glucocorticoid maintenance treatment may be more prone to recurrence.Acute-phase treatment with double filtration plasmapheresis may reduce the recurrence rate.
