Effect of Early Enteral Nutrition Intervention on Neurological Function,Nutritional Status,and Inflammatory Stress Response in Patients with Severe Traumatic Brain Injury
10.13241/j.cnki.pmb.2025.19.016
- VernacularTitle:早期肠内营养干预对重症脑外伤患者神经功能、营养状况及炎症应激反应的影响
- Author:
Mei-ling QIU
1
;
Qiu-yin GUO
1
;
Cong-ni CAI
1
Author Information
1. 石狮市医院神经外科 福建泉州 362700
- Publication Type:Journal Article
- Keywords:
Enteral nutrition;
Severe;
Traumatic brain injury;
Neurological function;
Nutritional status;
Inflammatory stress response
- From:
Progress in Modern Biomedicine
2025;25(19):3154-3161
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of early enteral nutrition(EN)intervention on neurological function,nutritional status,and inflammatory stress response in patients with severe traumatic brain injury.Methods:This study was a single-center prospective study,68 patients with severe traumatic brain injury were divided into control group[received parenteral nutrition(PN)intervention,n=34]and observation group(received early EN intervention,n=34)according to the envelope lottery method.The improvement of neurological function[serum central nervous system specific(S1 00(3)protein,national institutes of health stroke scale(NIHSS)score,myelin basic protein(MBP)],nutritional status[transferrin(TRF),total protein(TP),albumin(ALB)and prealbumin(PA)],inflammatory stress indicators[C-reactive protein(CRP),procalcitonin(PCT),glutathione peroxidase(GSH-PX),malondialdehyde(MDA)],daily living activity ability,quality of life,and incidence of complications between two groups were compared.Results:Compared with the control group after intervention,the observation group had lower NIHSS scores,S100[3 protein,MBP,CRP,PCT and MDA,had higher TRF,TP,ALB,PA,GSH-PX,improved Barthel index and world health organization quality of life assessment scale-100(WHOQOL-100)score(P＜0.05).There was no difference in the incidence of complications between the two groups(P＞0.05).Conclusion:Early EN intervention in patients with severe traumatic brain injury can effectively improve neurological function,nutritional status,and reduce the body's inflammatory stress response,which is worthy of clinical reference and application.
