Antimicrobial resistance profile of clinical isolates in hospitals across China:report from the CHINET Antimicrobial Resistance Surveillance Program,2023
- VernacularTitle:2023年CHINET中国细菌耐药监测
- Author:
Yan GUO
1
;
Fupin HU
;
Demei ZHU
;
Fu WANG
;
Xiaofei JIANG
;
Yingchun XU
;
Xiaojiang ZHANG
;
Fengbo ZHANG
;
Ping JI
;
Yi XIE
;
Yuling XIAO
;
Chuanqing WANG
;
Pan FU
;
Yuanhong XU
;
Ying HUANG
;
Ziyong SUN
;
Zhongju CHEN
;
Jingyong SUN
;
Qing CHEN
;
Yunzhuo CHU
;
Sufei TIAN
;
Zhidong HU
;
Jin LI
;
Yunsong YU
;
Jie LIN
;
Bin SHAN
;
Yunmin XU
;
Sufang GUO
;
Yanyan WANG
;
Lianhua WEI
;
Keke LI
;
Hong ZHANG
;
Fen PAN
;
Yunjian HU
;
Xiaoman AI
;
Chao ZHUO
;
Danhong SU
;
Dawen GUO
;
Jinying ZHAO
;
Hua YU
;
Xiangning HUANG
;
Wen'en LIU
;
Yanming LI
;
Yan JIN
;
Chunhong SHAO
;
Xuesong XU
;
Wei LI
;
Shanmei WANG
;
Yafei CHU
;
Lixia ZHANG
;
Juan MA
;
Shuping ZHOU
;
Yan ZHOU
;
Lei ZHU
;
Jinhua MENG
;
Fang DONG
;
Zhiyong LÜ
;
Fangfang HU
;
Han SHEN
;
Wanqing ZHOU
;
Wei JIA
;
Gang LI
;
Jinsong WU
;
Yuemei LU
;
Jihong LI
;
Qian SUN
;
Jinju DUAN
;
Jianbang KANG
;
Xiaobo MA
;
Yanqing ZHENG
;
Ruyi GUO
;
Yan ZHU
;
Yunsheng CHEN
;
Qing MENG
;
Shifu WANG
;
Xuefei HU
;
Hua FANG
;
Penghui ZHANG
;
Bixia YU
;
Ping GONG
;
Haixia SHI
;
Kaizhen WEN
;
Yirong ZHANG
;
Xiuli YANG
;
Yiqin ZHAO
;
Longfeng LIAO
;
Jinhua WU
;
Hongqin GU
;
Lin JIANG
;
Meifang HU
;
Wen HE
;
Jiao FENG
;
Lingling YOU
;
Dongmei WANG
;
Dong'e WANG
;
Yanyan LIU
;
Yong AN
;
Wenhui HUANG
;
Juan LI
;
Quangui SHI
;
Juan YANG
;
Abulimiti REZIWAGULI
;
Lili HUANG
;
Xuejun SHAO
;
Xiaoyan REN
;
Dong LI
;
Qun ZHANG
;
Xue CHEN
;
Rihai LI
;
Jieli XU
;
Kaijie GAO
;
Lu XU
;
Lin LIN
;
Zhuo ZHANG
;
Jianlong LIU
;
Min FU
;
Yinghui GUO
;
Wenchao ZHANG
;
Zengguo WANG
;
Kai JIA
;
Yun XIA
;
Shan SUN
;
Huimin YANG
;
Yan MIAO
;
Jianping WANG
;
Mingming ZHOU
;
Shihai ZHANG
;
Hongjuan LIU
;
Nan CHEN
;
Chan LI
;
Cunshan KOU
;
Shunhong XUE
;
Jilu SHEN
;
Wanqi MEN
;
Peng WANG
;
Xiaowei ZHANG
;
Xiaoyan ZENG
;
Wen LI
;
Yan GENG
;
Zeshi LIU
Author Information
- Publication Type:Journal Article
- Keywords: antimicrobial resistance surveillance; antimicrobial susceptibility testing; carbapenem-resistant gram-negative bacilli
- From: Chinese Journal of Infection and Chemotherapy 2024;24(6):627-637
- CountryChina
- Language:Chinese
- Abstract: Objective To monitor the susceptibility of clinical isolates to antimicrobial agents in healthcare facilities in major regions of China in 2023.Methods Clinical isolates collected from 73 hospitals across China were tested for antimicrobial susceptibility using a unified protocol based on disc diffusion method or automated testing systems.Results were interpreted using the 2023 Clinical & Laboratory Standards Institute (CLSI) breakpoints.Results A total of 445199 clinical isolates were collected in 2023,of which 29.0％ were gram-positive and 71.0％ were gram-negative.The prevalence of methicillin-resistant strains in Staphylococcus aureus,Staphylococcus epidermidis and other coagulase-negative Staphylococcus species (excluding Staphylococcus pseudintermedius and Staphylococcus schleiferi) (MRSA,MRSE and MRCNS) was 29.6％,81.9％ and 78.5％,respectively.Methicillin-resistant strains showed significantly higher resistance rates to most antimicrobial agents than methicillin-susceptible strains (MSSA,MSSE and MSCNS).Overall,92.9％ of MRSA strains were susceptible to trimethoprim-sulfamethoxazole and 91.4％ of MRSE strains were susceptible to rifampicin.No vancomycin-resistant strains were found.Enterococcus faecalis had significantly lower resistance rates to most antimicrobial agents tested than Enterococcus faecium.A few vancomycin-resistant strains were identified in both E.faecalis and E.faecium.The prevalence of penicillin-susceptible Streptococcus pneumoniae was 93.1％ in the isolates from children and and 95.9％ in the isolates from adults.The resistance rate to carbapenems was lower than 15.0％ for most Enterobacterales species except for Klebsiella,22.5％ and 23.6％ of which were resistant to imipenem and meropenem,respectively .Most Enterobacterales isolates were highly susceptible to tigecycline,colistin and polymyxin B,with resistance rates ranging from 0.6％ to 10.0％.The resistance rate to imipenem and meropenem was 21.9％ and 17.4％ for Pseudomonas aeruginosa,respectively,and 67.5％ and 68.1％ for Acinetobacter baumannii,respectively.Conclusions Increasing resistance to the commonly used antimicrobial agents is still observed in clinical bacterial isolates.However,the prevalence of important crabapenem-resistant organisms such as crabapenem-resistant K.pneumoniae,P.aeruginosa,and A.baumannii showed a slightly decreasing trend.This finding suggests that strengthening bacterial resistance surveillance and multidisciplinary linkage are important for preventing the occurrence and development of bacterial resistance.
