Changing antimicrobial resistance profiles of Staphylococcus and Enterococcus strains isolated from children:results from CHINET Antimicrobial Resistance Surveillance Program,2015-2021
- VernacularTitle:2015—2021年CHINET儿童患者临床分离葡萄球菌、肠球菌耐药性变迁
- Author:
Pan FU
1
;
Leiyan HE
;
Chuanqing WANG
;
Fupin HU
;
Yang YANG
;
Demei ZHU
;
Yingchun XU
;
Xiaojiang ZHANG
;
Fengbo ZHANG
;
Ping JI
;
Yi XIE
;
Mei KANG
;
Yuanhong XU
;
Ying HUANG
;
Ziyong SUN
;
Zhongju CHEN
;
Yuxing NI
;
Jingyong SUN
;
Yunzhuo CHU
;
Sufei TIAN
;
Zhidong HU
;
Jin LI
;
Yunsong YU
;
Jie LIN
;
Bin SHAN
;
Yan DU
;
Sufang GUO
;
Lianhua WEI
;
Fengmei ZOU
;
Hong ZHANG
;
Chun WANG
;
Yunjian HU
;
Xiaoman AI
;
Chao ZHUO
;
Danhong SU
;
Dawen GUO
;
Jinying ZHAO
;
Hua YU
;
Xiangning HUANG
;
Wen'en LIU
;
Yanming LI
;
Yan JIN
;
Chunhong SHAO
;
Xuesong XU
;
Chao YAN
;
Shanmei WANG
;
Yafei CHU
;
Lixia ZHANG
;
Juan MA
;
Shuping ZHOU
;
Yan ZHOU
;
Lei ZHU
;
Jinhua MENG
;
Fang DONG
;
Zhiyong LÜ
;
Fangfang HU
;
Han SHEN
;
Wanqing ZHOU
;
Wei JIA
;
Gang LI
;
Jinsong WU
;
Yuemei LU
;
Jihong LI
;
Jinju DUAN
;
Jianbang KANG
;
Xiaobo MA
;
Yanping ZHENG
;
Ruyi GUO
;
Yan ZHU
;
Yunsheng CHEN
;
Qing MENG
;
Shifu WANG
;
Xuefei HU
;
Jilu SHEN
;
Wenhui HUANG
;
Ruizhong WANG
;
Hua FANG
;
Bixia YU
;
Yong ZHAO
;
Ping GONG
;
Kaizhen WENG
;
Yirong ZHANG
;
Jiangshan LIU
;
Longfeng LIAO
;
Hongqin GU
;
Lin JIANG
;
Wen HE
;
Shunhong XUE
;
Jiao FENG
;
Chunlei YUE
Author Information
- Publication Type:Journal Article
- Keywords: Staphylococcus aureus; Enterococcus; antimicrobial resistance; children; China
- From: Chinese Journal of Infection and Chemotherapy 2024;24(6):678-689
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the changing distribution and antibiotic resistance (AMR) profiles of Staphylococcus spp.and Enterococcus spp.isolated from children in China.Methods A retrospective analysis was conducted on the Staphylococcus spp.and Enterococcus spp.isolated from children under 18 years in 52 hospitals participating in the CHINET program from January 2015 to December 2021.The results of antimicrobial susceptibility test (AST) were interpreted according to the Clinical and Laboratory Standards Institute (CLSI) breakpoints (2021 edition).Results In the 7-year period,46334 strains of Staphylococcus were isolated from children,including 32537 strains of S.aureus and 13797 strains of coagulase-negative Staphylococcus.Meanwhile,16287 strains of Enterococcus were isolated,including E.faecium (8434 strains) and E.faecalis (6525 strains).S.aureus strains were mainly isolated from lower respiratory tract specimens (43.4％±6.7％),wound secretions (27.8％±4.3％) and blood (6.2％±1.2％).Most of the E.faecalis strains (58.6％±5.1％) and E.faecium strains (62.9％±2.0％) were isolated from urine.Both Staphylococcus and Enterococcus strains were most frequently isolated from internal medicine wards.The prevalence of methicillin-resistant S.aureus (MRSA) and coagulase-negative Staphylococcus (MRCNS) was 29.5％ and 79.8％,respectively.The prevalence of MRSA was relatively high in neonates (0-28 days) and infants (>28 days to 1 year old),31.7％ and 30.9％,respectively.MRSA strains showed low and decreasing resistance rate to gentamicin,rifampicin,levofloxacin,and trimethoprim-sulfamethoxazole from 2015 to 2021.None of vancomycin-resistant or linezolid-resistant Staphylococcus was detected.Vancomycin-resistant or linezolid-resistant Enterococcus strains were rarely detected (0 to 1.0％).Moreover,more than 1.0％ of the E.faecalis isolates were resistant to linezolid in recent two years.Conclusions From 2015 to 2021,S.aureus,E.faecalis,and E.faecalis were still the most common gram-positive bacteria isolated from children.The prevalence of MRSA did not change significantly from 2015 to 2022.MRSA strains showed a trend of decreasing antimicrobial resistance.The antimicrobial resistance rates of E.faecalis and E.faecalis did not change significantly during the 7-year period.Ongoing AMR surveillance in the Staphylococcus and Enterococcus isolates from children is important for prevention,control,and treatment of the infections caused by Staphylococcus and Enterococcus in pediatric patients.
