Distribution and antimicrobial resistance profiles of clinical isolates from blood samples:results from China Antimicrobial Surveillance Network (CHINET) from 2015 to 2021
- VernacularTitle:2015—2021年CHINET血液分离菌的分布及耐药性变迁
- Author:
Min ZHONG
1
;
Xiangning HUANG
;
Hua YU
;
Yang YANG
;
Fupin HU
;
Demei ZHU
;
Yi XIE
;
Mei KANG
;
Shanmei WANG
;
Yafei CHU
;
Wenen LIU
;
Yanming LI
;
Dawen GUO
;
Jinying ZHAO
;
Yuanhong XU
;
Ying HUANG
;
Yunzhuo CHU
;
Sufei TIAN
;
Ziyong SUN
;
Zhongju CHEN
;
Yunsong YU
;
Jie LIN
;
Jihong LI
;
Yingchun XU
;
Xiaojiang ZHANG
;
Hui LI
;
Ping JI
;
Fang DONG
;
Zhiyong LÜ
;
Han SHEN
;
Wanqing ZHOU
;
Sufang GUO
;
Zhidong HU
;
Jin LI
;
Chuanqing WANG
;
Pan FU
;
Hong ZHANG
;
Chun WANG
;
Chao ZHUO
;
Danhong SU
;
Bin SHAN
;
Yan DU
;
Lixia ZHANG
;
Juan MA
;
Yuxing NI
;
Jingyong SUN
;
Jinju DUAN
;
Jianbang KANG
;
Yan JIN
;
Chunhong SHAO
;
Wei JIA
;
Gang LI
;
Xuesong XU
;
Chao YAN
;
Yunjian HU
;
Xiaoman AI
;
Jinsong WU
;
Yuemei LU
;
Fangfang HU
;
Lianhua WEI
;
Fengmei ZOU
;
Lei ZHU
;
Jinhua MENG
;
Shuping ZHOU
;
Yan ZHOU
;
Shifu WANG
;
Xiaobo MA
;
Yanping ZHENG
;
Kaizhen WEN
;
Yirong ZHANG
;
Yunsheng CHEN
;
Qing MENG
;
Xuefei HU
;
Ruizhong WANG
;
Hua FANG
;
Ruyi GUO
;
Yan ZHU
;
Jilu SHEN
;
Wenhui HUANG
;
Bixia YU
;
Jiao FENG
;
Yong ZHAO
;
Ping GONG
;
Shunhong XUE
;
Hongqin GU
;
Wen HE
;
Jiangshan LIU
;
Chunlei YUE
;
Longfeng LIAO
;
Lin JIANG
Author Information
- Publication Type:Journal Article
- Keywords: antimicrobial resistance surveillance; blood sample; pathogenic bacteria
- From: Chinese Journal of Infection and Chemotherapy 2024;24(6):664-677
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the distribution and antimicrobial resistance of bacterial isolates from blood samples in the hospitals participating in China Antimicrobial Surveillance Network (CHINET) from 2015 to 2021.Methods Bacterial strains isolated from blood samples were collected from 52 medical centers participating in CHINET from 2015 to 2021 for analysis of bacetrial distribution and antimicrobial resistance.Results A total of 153591 isolates were collected,48.8％ of which were gram-positive bacteria and 51.2％ were gram-negative bacteria.The top five bacterial strains were coagulase negative Staphylococcus (28.2％),Escherichia coli (20.7％),Klebsiella (13.7％),Enterococcus (7.2％),and Staphylococcus aureus (6.6％).Compard to female patients,male patients showed lower proportion of E.coli and higher proportions of other bacterial species in all the bacterial isolaets from blood samples.The proportions of Streptococcus pneumoniae and Salmonella in all the bacterial isolaets from blood samples were higher in children compared to adults.Enterobacterales species showed various resistance rates to antimicrobial agents.Overall,≥58.0％,≥36.8％ and ≥56.8％ of E.coli strains were resistant to cefotaxime,gentamicin and levofloxacin respectively over the 7-year period.However,less than 2.5％ of the E.coli strains were resistant to carbapenems.K.pneumoniae showed higher resistance rates to imipenem and meropenem than other Enterobacterales species.During the 7-year period,the prevalence of imipenem-resistant and meropenem-resistant K.pneumoniae increased from 21.4％ and 19.9％ in 2015 to 25.7％ and 26.6％ in 2021,respectively.However,carbapenems still maintained good antibacterial activity against other Enterobacterales,associaetd with lower resistance rates.In the 7-year period,Acinetobacter baumannii showed a dwonward trend in the resistance rates to imipenem and meropenem,but remained 72.9％ and 73.2％ respectively in 2021.The prevalence of imipenem-resistant and meropenem-resistant P.aeruginosa decreased from 26.7％ and 22.9％ in 2015 to 18.5％ and 14.7％ in 2021,respectively.The prevalence of PRSP was 1.5％ in the isolaets from adults and and 0.8％ in the isolates from children.Less than 3.0％ of the Enterococcus faecium and Enterococcus faecalis strains were resistant to vancomycin,teicolanin,or linezolid.The prevalence of methicillin-resistant S.aureus (MRSA) and coagulase negative Staphylococcus (MRCNS) was 32.1％ and 81.0％,respectively.The prevalence of MRSA was relatively stable,28.5％ in 2015 and 28.0％ in 2021.Conclusions Coagulase negative Staphylococcus,E.coli and K.pneumoniae were the main bacterial species isolated from blood samples in the hospitals participaing in the CHINET from 2015 to 2021.Significant sex and age differences were found in the distribution of bcterial isolates from blood samples.The overall resistance rates of the top bacetrial strains from blood samples to antimicrobial agents showed a downward trend.Ongoing surveillance of antimicrobial resistance for the isolates from blood samples is still essential for prescribing rational antimicrobial therapies and curbing bacterial resistance.
