T cell factor 1 regulates CD8 +T cell immunological and stemness
10.3760/cma.j.cn112309-20240630-00238
- VernacularTitle:T细胞因子1对CD8 +T细胞免疫记忆与干性的调控
- Author:
Yuning DAI
1
;
Ming GAO
1
;
Yanshi WU
1
;
Simin YUN
1
;
Siman HUANG
1
;
Yibei ZHU
1
Author Information
1. 苏州大学苏州医学院，苏州 215123
- Publication Type:Journal Article
- Keywords:
Immunological memory;
T cell factor 1;
CD8 +T cells;
Stem-like memory T cells;
Tumor immnuotherapy
- From:
Chinese Journal of Microbiology and Immunology
2025;45(11):974-978
- CountryChina
- Language:Chinese
-
Abstract:
T cell factor 1（TCF-1）is a downstream transcription factor of the Wnt/β-catenin signaling pathway，and plays an important role in the development，differentiation，and memory formation of T cells. Recent studies have shown that TCF-1 can regulate the formation and maintenance of stem-like memory T cells（Tscm），and has potential application value in evaluating the prognosis of tumor immunotherapy and as a target for tumor immunotherapy. This article reviews the regulatory effects of TCF-1 on the immune memory as well as stemness formation and maintenance of CD8 +T cells，summarizes the transcription network centered on TCF-1，and further elucidates the application and value of TCF-1 in tumor immunotherapy.
