Pathogenesis, pathological features, and progress in comprehensive treatment of cytokine storm in severe infections
10.3760/cma.j.cn112309-20240611-00206
- VernacularTitle:重症感染细胞因子风暴的发病机制、病理特征及综合治疗进展
- Author:
Hai ZOU
1
Author Information
1. 天津大学应急医学研究院，天津 300072
- Publication Type:Journal Article
- Keywords:
Severe infection;
Cytokine storm;
Diagnosis;
Treatment
- From:
Chinese Journal of Microbiology and Immunology
2025;45(7):611-618
- CountryChina
- Language:Chinese
-
Abstract:
Cytokine storm is a common and fatal pathological process in patients with severe infections. Its core mechanism involves the excessive activation of the immune system, leading to a massive release of cytokines, which in turn causes acute inflammatory responses and multiple organ failure. Studying the mechanisms and treatment methods of cytokine storm is of great significance for improving the survival rate of patients with severe infections. This paper systematically elucidates the pathogenesis, pathological characteristics, and current progress in the treatment of cytokine storm in severe infections, discusses the treatment strategies such as anti-inflammatory drugs, immunomodulatory therapy, and supportive care, and summarizes the results of clinical trials of emerging drugs and methods for treating cytokine storm, hoping to provide theoretical evidence and practical guidance for the precise diagnosis and treatment of cytokine storm and provide reference for clinical treatment of patients with severe infections.
