Association of cerebral white matter lesions with systolic and diastolic blood pressure
10.3969/j.issn.1002-0152.2025.01.002
- VernacularTitle:收缩压及舒张压与不同部位脑白质病变的相关性研究
- Author:
Mengjiao SUN
1
;
Yundong ZHANG
1
;
Jing CHEN
1
Author Information
1. 重庆医科大学附属第三医院神经疾病中心(重庆 401120)
- Publication Type:Journal Article
- Keywords:
Blood pressure;
Systolic blood pressure;
Diastolic blood pressure;
Cerebral small vessel disease;
White matter lesions;
Periventricular white matter lesions;
Deep white matter lesions
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(1):8-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of cerebral white matter lesions(WMLs)with systolic and diastolic blood pressure.Methods Patients admitted to our department from January 2023 to December 2023 were prospectively recruited for this study.The Fazekas method was used to grade the severity of the periventricular WMLs(P-WMLs)and deep WMLs(D-WMLs).Multivariate logistic regression analyses were performed to examine the association of systolic and diastolic blood pressure with WMLs.Results A total of 966 eligible participants were enrolled in this study.The mean age was 65.96±11.35 years and 487 participants(50.41%)were male.The results indicated that the more severe the P-WMLs and D-WMLs,the higher the systolic blood pressure was[P-WMLs:0:(134.41±19.86)mmHg,1:(136.82±20.47)mmHg,2:(144.52±21.64)mmHg,3:(147.80±20.7)mmHg;D-WMLs:0:(137.49±20.58)mmHg,1:(139.17±21.33)mmHg,2:(144.39±21.20)mmHg,3:(147.50±21.73)mmHg],but not diastolic blood pressure.Multivariate logistic regression analysis showed that an elevated systolic level(P-WMLs:OR=1.02,95%CI:0.009-0.021;D-WMLs:OR=1.01,95%CI:0.005-0.016)was associated with an increased risk of more severe of P-WMLs and deep D-WMLs.No significant association was observed between diastolic blood pressure and WMLs,whether for P-WMLs or D-WMLs.Conclusion The more severe P-WMLs and D-WMLs were,the higher the systolic blood pressure was.Elevated systolic blood pressure was an independent risk factors for more severe of P-WMLs and D-WMLs,but not diastolic blood pressure.
