African swine fever virus proteins modulate interferon response:Current research progress
10.16303/j.cnki.1005-4545.2025.11.29
- VernacularTitle:非洲猪瘟病毒蛋白调控干扰素应答研究进展
- Author:
Cuiying KONG
1
;
Zhao HUANG
;
Guihong ZHANG
;
Pei ZHOU
Author Information
1. 华南农业大学 兽医学院广东省兽医临床重大疾病综合防控重点实验室,广东 广州 510642;华南农业大
- Publication Type:Journal Article
- Keywords:
African swine fever virus;
interferon;
cGAS-STING;
RIG-I-MAVS;
JAK-STAT
- From:
Chinese Journal of Veterinary Science
2025;45(11):2535-2547
- CountryChina
- Language:Chinese
-
Abstract:
African swine fever(ASF),caused by the African swine fever virus(ASFV),is a highly lethal and hemorrhagic contagious disease.Following its introduction into China in 2018,the subse-quent widespread transmission of ASF has inflicted substantial economic losses on the domestic swine industry.ASFV,the sole member of the family Asfarviridae and genus Asfivirus,posses-ses a large double-stranded DNA genome ranging from 170 to 190 kbp and exhibits a structurally complex virion.Current research reveals that ASFV employs sophisticated strategies to evade host immune defenses,particularly through multifactorial modulation of critical nodes in the interferon(IFN)signaling pathway,thereby facilitating viral persistence.This article provides a review of current research on ASFV proteins involved in regulating type Ⅰ,Ⅱ,and Ⅲ interferon responses.It not only advances our understanding of viral pathogenesis but also provides crucial theoretical foundations for vaccine development,particularly for rationally designed gene-deleted vaccines.
