Structural abnormalities in patients with obsessive-compulsive disorder: a multimodal study
10.3760/cma.j.cn113661-20190731-00253
- VernacularTitle:强迫症患者脑结构异常的多模态研究
- Author:
Cong ZHOU
1
;
Zonglin SHEN
;
Fengrui ZHANG
;
Xiufeng XU
;
Yuqi CHENG
Author Information
1. 昆明医科大学第一附属医院精神科 650032
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Magnetic resonance imaging;
Diffusion magnetic resonance imaging
- From:
Chinese Journal of Psychiatry
2020;53(2):117-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether gray matter and white matter presented abnormalities in neural circuit in patients with OCD by using multimodal imaging strategies.Methods:Magnetic resonance imaging (MRI) scans from 54 OCD patients and 54 healthy controls (HC) were acquired. Gray matter volume was compared using the voxel-based morphometry (VBM) approach based on the SPM software. Fractional anisotropy (FA) difference was also evaluated using tract based spatial statistics (TBSS) based on the FSL software.Results:Compared with the HC, Patients with OCD showed decreased gray matter volume in the left middle frontal gyrus, left anterior cingulate and paracingulate gyri, left precental gyrus and right inferior temporal gyrus ( P<0.05, Alphasim corrected); meanwhile, decreased FA values in the body and genu of corpus callosum were found. Conclusions:Patients with OCD demonstrated widespread gray matter and white matter alterations especially in the incortico-striatal-thalamic-cortical (CSTC)circuit. Therefore, Patients with OCD might present altered gray and white matter structures simultaneously.
