Analysis of crotonylation protein expression in benign prostatic hyperplasia and its correlation with urodynamics parameters
10.3760/cma.j.cn112330-20240122-00031
- VernacularTitle:巴豆酰化修饰在前列腺增生组织中的表达及其与尿动力学参数的相关性分析
- Author:
Ting HU
1
;
Xiaojuan YUAN
1
;
Zhenqiang FANG
1
;
Zhenxing YANG
1
Author Information
1. 陆军军医大学第二附属医院泌尿外科，重庆 400037
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Crotonylation;
Urodynamics;
Post-translational modifications
- From:
Chinese Journal of Urology
2024;45(11):866-868
- CountryChina
- Language:Chinese
-
Abstract:
No research considering the expression of protein post-translational crotonylation in benign prostate hyperplasia (BPH), and the correlation between crotonylation and clinical urodynamic testing parameters. 176 BPH samples collected in our hospital were stained with crotonylation pan-antibody, and the correlation between staining scores and urodynamic test parameters were analyzed. The results showed that 14.77% of BPH tissues had high levels, 40.34% had moderate levels, and 44.89% had low levels of crotonylation modification in cytoplasm. 43.75% of BPH tissue cell nuclei were stained positive, of which 12 cases showed high levels, 18 cases had medium levels, and 47 cases had low levels of crotonylation modification. The volume of BPH tissue with high-level cytoplasmic crotonylation modified [(90.15±29.88) ml] was significantly higher than that of medium-level [(52.53±28.68) ml] and low-level [(43.33±19.65) ml] tissues ( P<0.001). Parameters from urodynamics including detrusor pressure and prostate plateau area were significantly higher in the high-level crotonylation group [(63.21±36.25) cmH 2O and (2 011.2±518.7) mm·cmH 2O]than those in the medium- [(45.0±25.4) cmH 2O and (1 319.1±564.4) mm·cmH 2O] and low-level [(37.1±19.5)cmH 2O and (1 496.4±520.1)mm·cmH 2O] groups ( P<0.01). High-level crotonylation modification is related to the proliferation of BPH tissue and the urodynamic performance of patients, which could be involved in the occurrence and development of BPH.
