Strategies for modulating angiogenesis and macrophage function in cardiovascular diseases
10.20039/j.cnki.1007-3949.2025.11.008
- VernacularTitle:心血管疾病的血管生成及巨噬细胞调控策略
- Author:
Dili SUN
1
;
Chun XIAO
;
Xiangdong YANG
Author Information
1. 复旦大学附属中山医院上海市心血管病研究所,上海市 200032
- Publication Type:Journal Article
- Keywords:
angiogenesis;
atherosclerotic cardiovascular diseases;
macrophage;
nanomaterials;
injury repair
- From:
Chinese Journal of Arteriosclerosis
2025;33(11):981-988
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is a critical process in the treatment of cardiac ischemic injury,and numerous research findings indicate that macrophages play a vital role in angiogenesis.This review summarizes how macrophages regulate an-giogenesis through the secretion of key factors and the interactions with other cells.M1 macrophages promote new blood vessel formation in the early stages by secreting pro-angiogenic factors,while M2 macrophages are involved in vascular re-modeling and maintaining vessel homeostasis.This review also discusses several new therapeutic strategies for promoting angiogenesis,including direct injection of macrophages,modulation of macrophage phenotype and function,and the use of macrophage-derived exosomes.Numerous studies have shown that macrophages have multiple functions in angiogenesis,and targeting macrophages provides new therapeutic targets and directions for promoting angiogenesis and treating ischemic diseases.
