Clinicopathological features and prognosis of early-onset prostate cancer
- VernacularTitle:早发性前列腺癌患者临床病理特征及预后分析
- Author:
Rongjie SHI
1
;
Yamin WANG
1
;
Tianbao HUANG
1
;
Ruizhe ZHAO
1
;
Lai DONG
1
;
Jinwei SHANG
1
;
Zhiyi SHEN
1
;
Kaiyu ZHANG
1
;
Lixin HUA
1
;
Gong CHENG
1
Author Information
- Publication Type:Journal Article
- Keywords: Prostatic neoplasms; Carcinoma; Early-onset; Progress free survival; Prognosis
- From: Chinese Journal of Urology 2024;45(10):789-790
- CountryChina
- Language:Chinese
- Abstract: A retrospective analysis was conducted on 5 516 patients diagnosed with prostate cancer(PCa) at our hospital. Among these, 52 patients aged ≤ 50 years were defined as the early-onset group.For the control group, 228 patients aged >50 years were randomly selected at a ratio of 1∶4.4. The early-onset group predominantly presented with elevated PSA levels at diagnosis and had a lower positive rate of digital rectal examination. There were no significant differences in clinical and pathological characteristics between the early-onset group and the control group. Young PCa patients in the low to intermediate risk categories had similar survival prognosis to older patients. However, young patients with high-risk prostate cancer had 5-year progression-free survival rate of 38.4% compared to 55.6% for older patients, and 5-year cancer-specific survival rate of 70.1% compared to 84.1% for older patients, indicating that high-risk young patients exhibited poorer oncological outcomes.
