Analysis of adverse drug reactions/events of coagulation abnormalities or bleeding caused by antibiotics
10.13699/j.cnki.1001-6821.2024.24.022
- VernacularTitle:抗菌素出凝血异常药物不良反应/事件分析
- Author:
Li ZUO
1
;
Hui LIU
;
Hai-qiang WU
;
Wen-yu WU
;
Jian-ru WU
;
Tian-hua ZHONG
;
Xiao-yu LIU
;
Ming-qun ZHANG
;
Shu-kun LAI
Author Information
1. 深圳市药物警戒和风险管理研究院,广东 深圳 518024
- Publication Type:Journal Article
- Keywords:
antibiotic;
coagulation abnormalities or bleeding;
adverse drug reactions/events
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(24):3631-3634
- CountryChina
- Language:Chinese
-
Abstract:
Objective By analyzing adverse drug reactions/events(ADR/E)of coagulation abnormalities or bleeding caused by antibiotics to summarize monitoring points and provide clinical reference for the safe and rational use of antibiotics.Methods The data of 394 cases of ADR/E with coagulation abnormalities or bleeding of antibiotics reported from January 2014 to June 2023 in Shenzhen were retrospectively analyzed,focus on analysis:Ages,types of antibiotics involved,latency period of the ADR/E,affected organs and clinical manifestations of coagulation abnormalities,and the severity of the ADR/E.Results The age group with a significantly larger number of cases was 50-89 years old.The third-generation cephalosporin caused the most coagulation abnormalities or bleeding,accounting for 72.84％,of which cefoperazone compound preparations ranked first.The highest proportion of abnormalities occurred within one week of medication use.The most affected system-organ by coagulation abnormalities is the blood and lymphatic system,representing 62.42％of cases.The most frequent clinical manifestation is coagulation disorder.The severe cases of abnormal coagulation caused by antibiotics were more than half.Conclusion Coagulation abnormalities or bleeding induced by antibiotic usually cause serious health damage to patients.Medical staff should continue to monitor the patients with abnormal coagulation closely,especially the follow-up of middle-aged and elderly patients,and ensure the safety of patients.
