The efficiency of the brain structural networks and its relationship with the severity of disease in depression
10.3760/cma.j.issn.1006-7884.2014.06.001
- VernacularTitle:抑郁症患者脑结构网络效率属性及与疾病严重程度的相关分析
- Author:
Jianhuai CHEN
1
;
Zhijian YAO
;
Jiaolong QIN
;
Hao TANG
;
Rui YAN
;
Lingling HUA
;
Qing LU
Author Information
1. 210029,南京医科大学附属脑科医院抑郁症专科
- Publication Type:Journal Article
- Keywords:
Depression;
Diffusion magnetic resonance imaging;
Brain structural network;
Efficiency
- From:
Chinese Journal of Psychiatry
2014;47(6):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the differences of the efficiency of the networks and the nodes between the depression and the healthy,the changes of the model of information processing across the whole brain and the efficiency of information integrating across brain regions of the depression and the relationship between the global efficiency of the nodes and the severity of the disease.Methods The diffusion tensor imaging data were obtained from 27 depressive patients and 36 healthy controls.The whole cerebral cortex was divided into 90 regions by the anatomical tabel map.Fiber tracking was performed in the whole cerebral cortex of each subject to reconstruct white matter tracts of the brain using the fiber assignment by continuous tracking algorithm.And then the brain structural binary networks were constructed using the complex network theory.The efficiency of the brain structural networks of the depression and healthy were examined by two sample t-tests.Results The brain structural networks of both the depression and the healthy exhibited a higher local efficiency and a similar global efficiency when compared with the matched random networks.But the global efficiency of the brain structural networks of the depression (0.86 ± 0.01) decreased significantly when compared with the healthy (0.87 ± 0.01 ; t =-2.31 ; P =0.02).And the global efficiency of the nodes in the networks of depression (the right superior frontal gyrus (orbital part):0.41 ± 0.04 ; the left middle temporal gyrus (temporal pole):0.31 ± 0.02) decreased significantly when compared with the healthy (0.44 ± 0.02,0.33 ± 0.03 ; t =-3.52,-3.84 ; P =0.0008,0.0003,survived critical false discorery rate threshold for multiple comparisons).Significant negative correlation was found between the global efficiency of the right superior frontal gyrus (orbital part) and the total scores of HAMD-17 (r =-0.46,P =0.02).Conclusion Efficient small-world properties when processing information across the whole brain could exhibit in both the depressive patients and the healthy persons.But the efficiency of information integrating across brain regions may be decreased in the depressive patients and be negatively related with the severity of depression.
