The operational criterion and its validity of remission of major depressive disorder
10.3760/cma.j.issn.1006-7884.2014.04.005
- VernacularTitle:抑郁症临床治愈的指标及其有效性研究
- Author:
Ruixiang CAO
1
;
Hui MA
;
Hua YANG
;
Juan YANG
;
Houyuan LUO
;
Haitao QU
;
Ning ZHANG
Author Information
1. 南京师范大学心理学院
- Publication Type:Journal Article
- Keywords:
Major depressive disorder;
Hamilton Depression Scale;
Validation studies
- From:
Chinese Journal of Psychiatry
2014;47(4):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the optimal cutoff point defining remission on 17-item Hamilton Depression Scale (HAMD17) for major depressive disorder (MDD),and examine the validity of this cutoff point.Method We interviewed 251 MDD responders with the HAMD17,Global Assessment of Functioning,Generic Quality of Life Inventory.Results After acute phase treatment for MDD,even the HAMD17 scored 7 or less,92.3％ (203/220) of remitters had at least one subthreshold depressive symptoms,48.6％ (107/220) of them also experienced functioning impairment,when psychosocial functioning taken into account,a cutoff of ≤ 3 might be the operational criterion of MDD remission.Compared to MDD patients scoring 4-14 on HAMD17,patients scoring 0-3 had significantly better psychological functioning,social functioning and physical functioning (separately 60.1 ± 15.4 vs.52.0 ± 12.3,62.0 ± 11.2 vs.54.0 ± 11.0,60.5±14.3vs.52.7±10.2; t=3.307,4.119,3.626,all P＜0.01).Compared to4-14 score group,the rate of ones with psychosocial functioning being normal in 0-3 score group was higher (74.2％ vs.12.6％ ; x2 =97.10,P ＜ 0.01).Conclusion The results indicate that patients with MDD whose score of ≤3 on HAMD17 after the acute phase treatment may have better psychosocial functioning than those whose score of ＞ 3,suggesting this criterion be valid.
