Research Advances in Weight Loss Medications Combined with Nutritional Intervention
10.3870/j.issn.1004-0781.2025.12.006
- VernacularTitle:药物减重联合营养干预的研究进展
- Author:
Yifan GAO
1
;
Jianzhen YE
;
Huangli CHEN
;
Feng GAO
Author Information
1. 华中科技大学同济医学院附属同济医院医务处,武汉 430030
- Publication Type:Journal Article
- Keywords:
Obesity;
Drug induced weight loss;
Nutritional intervention;
Weight loss effect;
Adverse reactions
- From:
Herald of Medicine
2025;44(12):1914-1921
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is a non-communicable chronic disease whose increasing prevalence has contributed to a higher incidence of various obesity-related comorbidities,including type 2 diabetes,cardiovascular and cerebrovascular diseases,hyperlipidemia,hypertension,hyperuricemia,fatty liver disease,infertility and certain types of cancer.Nutritional intervention serves as the first-line and continuous approach in obesity management.However,its effectiveness heavily depends on patient compliance,which poses a challenge for some individuals and may lead to suboptimal weight loss outcomes.Pharmacotherapy has emerged as an important strategy for weight reduction due to its efficacy and convenience.Nonetheless,weight-loss medications are associated with limitations such as specific indications,adverse effects,and loss of muscle mass,highlighting the essential role of appropriate nutritional support as a foundation for drug therapy.This article reviewed the mechanisms of action,efficacy and common adverse reactions of the six weight-loss drugs approved in China,with a focus on the impact of combined nutritional interventions on enhancing treatment outcomes and mitigating adverse effects.The aim is to provide insights and evidence for optimizing clinical management strategies for obesity.
